摘要
目的:研究胎盘提取物(PIP)对减轻肿瘤化疗的毒性,增强疗效的效果。方法:采用动物实验方法,对荷瘤动物施于化疗的同时加喂PIP,观察抑制率和白细胞总数的变化。结果:化疗同时给予PIP,能显著提高抑制率(STR)(P<0.05);能迅速回升因化疗造成的外周血白细胞减少(P<0.01)。结论:在肿瘤化疗中PIP可协同抑制肿瘤,提高外周血中白细胞总数,进而调节生理功能,修复受损的组织或细胞。与其含有大量活性物质,提高机体免疫功能和抑瘤作用有关。
Objective： To study the effect on decreasing chemotherapeutic toxicity and increasing anti-tumor treatment of placental immunoregulating polypeptlde （PIP）. Methods： The change of suppressor tumor rate （STR） and leukocyte number in mice were observed by using PIP during chemotherapy. Results： Chemotherapy and using of PIP at the same time raised STR and increased leukocytes more rapidly than control. There were significant differences （ P 〈0.05, P 〈0.01 ） between two groups. Conclusions： PIP can inhibit the tumor, increase leukocytes and repair the damaged tissue and cells. It may be related to active material in PIP and improvement immunologic function and suppression tumor of PIP.
出处
《沈阳医学院学报》
2006年第2期88-89,共2页
Journal of Shenyang Medical College
基金
辽宁省科技攻关课题(00225003)
