摘要
目的探讨有效阻断乙型肝炎病毒在配偶间传播的免疫方案。方法随机抽取全省13个市县在婚前医学检查中筛查出HBsAg阳性、HBeAg阳性且肝功能正常的255例携带者的配偶为研究对象,其肝功能正常且乙肝血清标志物均阴性。将研究对象随机分成3组:联合免疫组、单纯乙肝疫苗免疫组和对照组,对各组采取不同的免疫方案,12个月后分别检测研究对象的肝功能和乙肝血清标志物,并对其进行问卷调查。结果12个月后,联合免疫组和单纯乙肝疫苗免疫组HBsAb阳性率均明显高于对照组,而HBsAg阳性率明显低于对照组,差别有显著性意义(P<0.001),联合免疫组与单纯乙肝疫苗免疫组HBsAb阳性率间差别无显著性意义(P>0.05)。各组HBsAb阳性率及HBsAg阳性率男、女间差别无显著性意义(P>0.05)。除联合免疫组外,单纯乙肝疫苗免疫组和对照组的HBsAg阳性率城乡间差别有显著性意义(P<0.05),农村被检者HBsAg阳性率高于城市。结论全程单纯接种乙肝疫苗或与乙肝高效价免疫球蛋白(HBIG)联合注射能使大多数人产生乙肝表面抗体(HBsAb),可有效阻断HBV在配偶间的传播。HBIG在保护那些在完成免疫全程前已结婚或婚前短时间同居的配偶时起到了关键作用。
Objective To explore the efficient immunity methods preventing the transmission of Hepatitis B Virus （HBV） in newly - married young spouse, Methods 255 HBV carriers with positive HBsAg ＆ HbeAg and normal liver function in 13 cities or countries were randomly selected. Their spouses with normal liver function and negative serological markers of hepatitis B were investigated in this study. Their spouses were randomly divided into three groups： （ 1 ） combined immunity group （CI Group）; （2） simple hepatitis B vaccine immunity group （SV Group）; （3） control group （Control Group）. Each group was treated with different immunity method. 12 months later, their blood serum was examined to investigate their liver function and hepatitis B serological markers, at the same time, the questionnaires were performed. Results The positive rates of HBsAb in CI Group and SV Group were significantly higher than that in control group after 12 months （ P 〈0. 001 ）. There wasn＇t significant difference between CI group and SV group （ P 〉 0.05 ）. The positive rates of HBsAg in CI Group and SV Group were significantly lower than that in control Group （ P 〈0.001 ）, there was no significant difference between CI Group and SV Group （ P 〉0. 05）. In this research, both the positive rates of HBsAb and HBsAg in three groups didn＇t show sexual difference respectively （ P 〉 0. 05）. Additionally, we found the positive rate of HBsAb in the three groups wasn＇t related to the resident area （urban or rural）, but the positive rates of HBsAg in SV group and control group were significantly higher in rural than in urban （ P 〈0.05）. Conclusion Hepatitis B or/and Hepatitis B immunoglobulin （HBIG） can make many people produce enough HBsAb to prevent the transmission of HBV in newly - married young spouses. Hepatitis B immunoglobulin （HBIG） plays an important role in protecting the young couples who married before finishing the whole vaccination procedure or lived together for
出处
《中国全科医学》
CAS
CSCD
2006年第12期981-982,985,共3页
Chinese General Practice
基金
河北省2005年医学科学研究重点课题(05355)
关键词
肝炎病毒
乙型
免疫球蛋白疗法
肝炎疫苗
乙型
疾病传播
水平
Hepatitis B virus
Immunization therapy
Hepatitis B vaccines
Disease transmission, horizontal
