摘要
目的:观察不同中医证型阴茎勃起功能障碍患者的药物性阴茎勃起实验和阴茎血流动力学表现,调查该病危险因素分布情况,并与动脉性勃起功能障碍进行对照。方法:①选择2003-01/2005-01在深圳市梅林医院泌尿外科就诊或住院治疗的主诉阴茎勃起功能障碍患者131例,年龄31～68岁。选择同期在本院经药物性阴茎勃起实验和彩色多普勒超声检查确诊的动脉性勃起功能障碍患者35例,年龄39～71岁。纳入对象均对检测项目知情同意。②参照1993年卫生部《中药新药临床研究指导原则》关于“中药新药治疗阳痿的临床研究指导原则”所确定的辨证标准,并结合第二届全国活血化瘀研究学术会议修订的《血瘀证诊断标准》和临床实际,初步拟设3个证型:肝郁证68例,肾虚证43例,血瘀证20例。③在阴茎一侧海绵体内注射罂粟碱30～60mg加酚妥拉明2mg,刺激勃起。勃起状态判定采用Porst分级法:0级为完全没有反应;1级为轻微勃起;2级为不完全勃起;3级为正常勃起。阴茎勃起时间指阴茎充分勃起回复到萎软状态之间的时间。④采用AlokaSSD-1700型彩色多普勒超声诊断仪测定收缩期最大血流速度、舒张末期血流速度、血流阻力指数。⑤根据世界卫生组织相关论断标准判定勃起功能障碍患者危险因素:高脂血症、高血压、糖尿病、冠心病和肥胖患病情况。通过询问病史了解患者年龄、病程,计算吸烟指数(每日吸烟支数×吸烟年数)。结果:中医诊断为勃起功能障碍131例和动脉性勃起功能障碍患者35例均进入结果分析,无脱落者。①肝郁证和肾虚证阴茎勃起功能障碍患者平均阴茎勃起时间明显短于血瘀证型和对照组(P<0.05),Porst分级、双侧收缩期最大血流速度明显高于血瘀证型和对照组(P<0.05)。各中医证型与动脉性阴茎勃起功能障碍患者双侧舒张末期血流速度、双侧血流阻力指数相近。②�
AIM： To investigate the experiment of drug penile erection （PE） and hemedynamical changes of thysus of patients with penile erectile dysfunction （PED） by using different dialectical types of traditional Chinese medicine, and explore the distribution of risk factors, so as to compare it with arterial ED.
METHODS： ①A total of 131 patients of chief complaint with PED aged from 31 to 68 years were selected from the Department of Urinary Surgery, Shenzhen Meilin Hospital between January 2003 and January 2005. Among them, 35 cases aged·39-71 years were diagnosed as arterial ED with PE experiment and color Doppler ultrasonic examination. All subjects were informed and agreed the detection. ②Aecording to the “Clinical Researching Criteria of New Drugs and Traditional Chinese Medicine in Treating Erectile Dysfunction” established by the National Ministry of Public Health in 1993 and the Standard for Diagnosis Evaluation on Blood Stasis Syndrome revised by the Second Chinese Blood-activating Stasis-elimination Research Academic Meeting, three types were initially assumed： syndrome of stagnation of liver （n=68）, renal deficiency （n=43） and syndrome of blood stasis （n=20）. ③30-60 mg cardoverine and 2 mg phentolamine were injected into unilateral cavernous body of thysos to stimulate erection. States of erection were determined with Porst grading technique： Grade 0： complete unreaction; Grade 1： light erection; Grade 2： imcomplete erection; Grade 3： normal erection. Duration of PE was the time from sufficient PE till atrophy. ④Value of peak blood flow velocity at systolic phase, blood flow rate at diastasis, and index of resistance of blood flow were measured with AlokaSSD-1700 color Doppler ultrasonograph. ⑤Risk factors of ED, such as hyperlipemia, hypertension, diabetes mellitus, coronary artery disease and corpulency, were assessed on the basis of relative criteria established by the World Health Organization. Smoking index （numbers of daily smoking × years） of pati
出处
《中国临床康复》
CSCD
北大核心
2006年第23期19-21,共3页
Chinese Journal of Clinical Rehabilitation
