摘要
肿瘤坏死因子转化酶(TACE)已经成为治疗关节炎、癌症、糖尿病和HIV恶病质等疾病的一种潜在新靶点。通过对国外近几年来出现的新型TACE小分子抑制剂的介绍,旨在对现有抑制剂进行筛选和结构改造,进一步提高TACE抑制剂的选择性,降低体内代谢毒性。
Tumor necrosis factor （TNF）-converting enzyme （TACE） has emerged as a potential therapeutic target in the areas of arthritis, cancer, diabetes and HIV cachexia. The recent advance of the study on TACE inhibitors, which describes the discovery of some new small molecule TACE inhibitors, is reviewed in this article.
出处
《中国药物化学杂志》
CAS
CSCD
2006年第3期188-192,共5页
Chinese Journal of Medicinal Chemistry
