摘要
目的:对本院病案资料中GIST重新分类,加强对胃肠道间质瘤的认识。方法:用CD117、CD34、α-SMA、S-100等抗体对56例GIST进行标记、分类,根据GIST的临床病理及形态学特点,正确诊断,并探讨GIST的临床特点。结果:56例GISTCD117、CD34弥漫强表达,抗体阳性率分别为CD117(50/56,89·3%)、CD34(37/56,66·1%),部分病例局灶表达α-SMA、S-100,阳性率分别为(17/56,30·4%)、(4/56,7·1%),结蛋白desmin均阴性。其中良性及交界性29例,恶性27例。本组病例中胃及小肠GIST共达91·1%,其它部位少见。结论:CD117、CD34在GIST表达显著,可作为GIST诊断的一个辅助指标。胃和小肠GIST最常见,胃镜等影像学无特异性,诊断主要依靠病理诊断。组织病理不仅有助于诊断,而且有助于预后的判断。
AIM： In this article, gastrointestinal tumor - related historical archives of pathology in our hospital were reviewed in order to acknowledge gastrointestinal stromal tumors （GIST）. METHODS： These eases were rediagnosed correctly , these tissues were labeled with some antibodies such as CD117, CD34, α- SMA, S- 100, and their clinical characteristics were explored. RESULTS： CD117, CD34 were expressed widely in GISTs ,the percentage of positive expression was CD117 （50/56, 89.3%）, CD34 （37/56, 66.1%）, respectively, α- SMA, S- 100 were （17/56, 30.4%）, （4/56, 7.1%）, respectively, desmin was negative in these cases. Among them, 29 cases were benign and borderline, 27 cases were malignant. The percentage of occurring in stomach and intestine was 91.1%. CONCLUSION： CD117, CD34 are expressed significantly in GIST, these might be assistant markers for GIST diagnosis. GISTs mostly occurred in stomach and intestine.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2006年第6期1222-1224,共3页
Chinese Journal of Pathophysiology
