摘要
目的:评价国产美罗培南对重症革兰阴性菌感染的临床疗效和体外病原菌的药敏情况。方法:对20例应用国产美罗培南治疗重症革兰阴性菌感染的患者进行回顾性分析。结果:国产美罗培南治疗重症革兰阴性菌感染有效率80%;体外敏感性显示,美罗培南对革兰阴性菌敏感率最高(82.14%),而且对头孢他啶和头孢哌酮/舒巴坦耐药的菌株具有很好的敏感性,其敏感率分别为77.27%和80%。结论:对第3代头孢菌素和酶抑制剂复合制剂耐药的革兰阴性菌重度感染可以应用美罗培南作为经验性治疗。
Objective：To evaluate the clinical efficacy of meropenem on patients with severe gram-negative bacterial infection and to analyze drug sensitivity in vitro. Methods：To analyze retrospectively of meropenem on 20 cases with severe gram-negative bacterial infection. Results：The effective rate of meropenem was 80 %. The sensitivity rate of meropenem to gram-negative bacterium in vitro was the highest （82.14 %）,The strains of drug resistance to ceftazidime and cefoperazone/ sulbactam were sensitive to meropenem,whose sensitivity rates to meropenem were 77.27 % and 80 %, respectively. Conclusion： Severe gram-negative bacterial infection of drug resistance to the third generation cephalosporin and enzyme inhibitor compound preparation may be treated by meropenem.
出处
《抗感染药学》
2006年第2期56-58,共3页
Anti-infection Pharmacy
关键词
美罗培南
革兰阴性菌
敏感性
Meropenem
gram-negative bacterium
drug sensitivity
