摘要
AIM： To detect the therapeutic effects of chemical destruction of celiac ganglion in patients with pancreatic carcinoma with intractable pain. METHODS： Ninety-seven cases with advanced pancreatic carcinoma received chemical destruction of celiac ganglion-5 mL pure alcohol injection around celiac artery under ultrasonic guidance. The changes of visual analogue scale （VAS）, serum substance P （Sub P）, β-endopeptide （β-EP） and T-lymphocyte subtypes level were compared between pre- and post-therapy. RESULTS： Successful rate of puncture was 98.7%, with one failure. No serious complications such as traumatic pancreatitis, pancreatic fistula, abdominal cavity hemorrhage or peritoneal infection occurred. VAS, serum Sub P and β-EP level significantly changed after treatment （8.0 ± 2.3 vs 4.6 ± 2.1, 254.1 ± 96.7 vs 182.4 ± 77.6, 3.2 ± 0.8 vs 8.8 ± 2.1, P 〈 0.01, P 〈 0.05, P 〈 0.01） with complete relief rate 54.2%, partial relief rate 21.9%, ineffective rate 12.5% and recurrent rate 10.7%. The T-lymphocyte subtypes level remarkably increased when compared with that of pre-therapy （46.7 ± 3.7 vs 62.5 ± 5.5, P 〈 0.01）. CONCLUSION： Our study suggests that chemical destruction of celiac ganglion under ultrasonic guidance is highly safe, and can evidently relieve cancer pain and improve the cellular immunity in patients with advanced pancreatic carcinoma.
瞄准：难处理的疼痛地与胰腺的癌在病人检测腹的中心的化学破坏的治疗学的效果。方法：有先进的胰腺的癌的 97 个盒子收到了腹的 ganglion-5 mL 的化学破坏在在超声的指导下面的腹的动脉附近的纯白酒注射。视觉类似物规模(管) 的变化，浆液物质 P (潜水艇 P ) ， beta-endopeptide (beta-EP ) 和子类型铺平的 T 淋巴细胞在治疗前之间被比较并且治疗以后。结果：刺的成功的率是 98.7% ，与一失败。象创伤的胰腺炎，胰腺的管，腹的洞出血或腹感染那样的严肃的复杂并发症都没发生。管，浆液潜水艇 P 和 beta-EP 水平显著地改变了术后疗法(8.0+/-2.3 对 4.6+/-2.1， 254.1+/-96.7 对 182.4+/-77.6， 3.2+/-0.8 对 8.8+/-2.1， P<0.01， P<0.05， P<0.01 ) 与完全的消除率 54.2% ，部分地势评估 21.9% ，无效的率 12.5% 并且周期性的率 10.7% 。T 淋巴细胞子类型水平显著地增加了什么时候与治疗前的相比(46.7+/-3.7 对 62.5+/-5.5， P<0.01 ) 。结论：我们的学习建议在超声的指导下面的腹的中心的那化学破坏是高度安全的，并且能显然减轻癌症疼痛并且与先进的胰腺的癌在病人改进细胞免疫。
