摘要
最近德国科学家Burmester等发现神经组织中存在一类携氧球蛋白，把这类主要在脑、视网膜及内分泌组织中表达的第3类携氧球蛋白称为脑红蛋白（NGB）。此蛋白可在缺氧条件下为神经组织供氧5～31min，且具有加速氧向神经组织转运的功能。NGB在低氧预适应过程中起重要作用：NGB的含量越低对缺氧的耐受性越差。NGB基因表达的调控至少有3条信号转导途径参与。视网膜的相对耗氧量高于全身各组织器官，缺氧将直接导致视觉传导过程的严重障碍。NGB的发现，为视网膜缺氧的研究指出了新方向，为缺氧性视网膜损伤的防治提供了新的思路。
Burmester et al, a group of German scientists, found a kind of oxygen-carrying globulin in the neurotissue recently. Neuroglobin is used to name the third kind of oxygen-carrying globulin,which mainly was expressed in brain,retina and endocrine tissues. The oxygen-carrying function of neuroglobin is its abilities of supplying oxygen for 5 to 31 minutes under the hypoxia condition and accelerating the oxygen transportation to nerve tissue. Neuroglobin plays important roles during the hypoxic preconditioning, that is, the less neuroglobin level in tissue is, the lower the tolerable capacity of tissue to hypoxic condition. NGB gene expression is mediated by at least 3 signal transduction pathways. Retina is the highest oxygen-consuming tissue in the body. Hypoxia is known to have rapid and adverse effects on visual performance of man and other vertebrates. Neuroglobin offers a potential approach to the study of hypoxic retinal injury.
出处
《眼科研究》
CSCD
北大核心
2006年第3期334-336,共3页
Chinese Ophthalmic Research
