摘要
目的:观察外用重组人表皮生长因子(rhEGF)对面部Ⅱ度烧伤创面的治疗作用和安全性。方法:随机选择成年女性面部浅Ⅱ度烧伤、深Ⅱ度烧伤各60例,进行随机、双盲、同体试验;每例患者选择一块浅Ⅱ度或深Ⅱ度烧伤创面,并将其分为面积相近的两部分作为治疗组及对照组;伤后3 d起,治疗组采用含rhEGF的等渗盐水纱布覆盖创面,对照组单用等渗盐水纱布覆盖创面,每日换药1次至创面愈合。观察中期创面愈合率、愈合时间、疼痛情况及Ⅱ度创面愈合后的瘢痕指数。结果:对浅Ⅱ度烧伤创面,治疗组的7 d愈合率显著高于对照组[(77．18±13．36)%vs．(58．97±10．39)%,P＜0．01],愈合时间显著短于对照组[(9．92±2．48)d vs．(12．07±3．05)d,P＜0．01]。对深Ⅱ度烧伤创面,治疗组的14 d愈合率显著高于对照组[(75．93±22．02)%vs．(62．26±19．25)%,P＜0．01],愈合时间显著短于对照组[(17．12±3．69)d vs．(21．06±3．87)d,P＜0．01],瘢痕指数明显低于对照组[(8．12±1．47)vs．(9．79±1．85),P＜0．01]。治疗过程未见明显不良反应。结论:外用rhEGF能显著加快面部Ⅱ度烧伤创面的愈合速度,缩短愈合时间,提高愈合质量,减少瘢痕的形成,无明显不良反应,安全性好。
Objective：To explore the therapeutic effect and security of recombinant human epidermal growth factor（rhEGF） for the facial burn wounds of degree Ⅱ. Methods ：60 cases of facial superficial degree Ⅱ burn patients and 60 cases of facial deep degree Ⅱ burn patients were enrolled in this study and were observed by randomized, double-blinded and placebo-controlled protocol. An area of degree Ⅱ burn wounds from each patient was divided into control （C） and treatment （T） portions. The wound in C was treated with normal saline gauzes while that in T with rhEGF gauzes. Dressing change everyday until the wounds healing. Results ：In therapeutic group, the wounds healing speed is accelerated, the healing time is shorten （P 〈 0.01 ） and the healing ratio on synchronization is promoted （P 〈 0. 01） than the control group. The pain without exacerbating and with less scars formation. Without obvious side effects or dys-response in the therapeutic process. Conclusions：rhEGF can accelerate obviously the healing speed,lessen the healing time on the facial burn wounds of degree Ⅱ and can promote the healing quality with less scars formation, rhEGF is effective and safe to the wounds.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2006年第10期812-814,共3页
Chinese Journal of New Drugs
关键词
重组人表皮生长因子
Ⅱ度烧伤
创面愈合
recombinant human epidermal growth factor （rhEGF）
degree Ⅱ burn
wound healing
