摘要
肾素血管紧张素系统(RAS)已被证明参与了骨髓造血细胞的生长增殖和分化,而再生障碍性贫血(AA)被认为是与骨髓造血细胞受损和造血微环境缺陷有关的疾病。为了探讨AA的发病机制,运用放射免疫方法检测22例AA患者骨髓和外周血肾素活性及AngⅠ、AngⅡ浓度,并以16例外周血常规和骨髓检查正常的患者为对照组,比较两组之间的差异。结果发现:AA组骨髓AngⅡ浓度低于对照组(P<0.01),AA组的骨髓AngⅡ浓度与外周血比较差异无统计学意义(P>0.05),对照组的骨髓AngⅡ浓度较同组的外周血高(P<0.01),两组的肾素活性及AngⅠ浓度差异无统计学意义(P>0.05)。结论:AA患者骨髓AngⅡ浓度降低,AA发病可能与其有关。
Renin-angiotensin system （RAS） has been shown to be involved in the growth, production, proliferation and differentiation of the bone marrow （BM） hematopoietic cells, while aplastic anemia （AA） is a disease in which proliferation ability of the BM hematopoietic cells is damaged with defective hematopoietic micrcenvironment. To investigated the pathogenesis of AA, the rennin activity, angiotensin Ⅰ （Ang Ⅰ） and angiotensin Ⅱ （Ang Ⅱ ） concentration in peripheral blood and BM of 22 AA patients were detected by radioimmunnoassay, 16 nonhematological disease patients with nomal blood counts and BM picture were used as control, and the differeence between two groups was compared. The results showed that BM Ang Ⅱ concentration in the AA patients was significantly lower than that in the control （ P 〈 0.01 ）. In nonhematological disease patients, Ang Ⅱ concentration in BM was significantly higher than that in peripheral blood, the renin activities and Ang Ⅰ concentrations were not significantly different in the two groups （ P〉0.05 ）. In conclusion, the decreased BM Ang Ⅱ concentration in AA patients may be involved to the pathogenesis of AA.
出处
《中国实验血液学杂志》
CAS
CSCD
2006年第3期512-515,共4页
Journal of Experimental Hematology
