摘要
目的：研究自发性高血压大鼠降压前后的机械痛阈和热痛阈改变.方法：15只自发性高血压大鼠在实验 d 4～11肌注利血平注射液（1 μg·kg^-1·d^-1）.血压、机械刺激缩足反应阈值和热刺激缩足反应潜伏期作为观察指标.结果：自发性高血压大鼠经利血平降压治疗后血压明显下降约 50 mmHg 左右,机械痛阈和热痛阈均降低（P＜0.05）.结论：自发性高血压可能对自发性高血压大鼠的伤害性感受系统存在可逆的结构和（或）功能影响.
AIM： To study the effect of decreasing blood pressure on mechanical and heat pain sensitivity in spontaneously hypertensive rats. METHODS： 15 SHRs were intramuscularly given reserpine （ 1 μg·kg^-1·d^-1） on day 4-11. Blood pressure, paw withdrawal mechanical threshold （PWMT） and paw withdrawal thermal latency （PWTL） were measured every day. RESULTS： After the therapy of reserpine in spontaneously hypertensive rats, blood pressure decreased by 50 mmHg, mechanical and heat pain threshold were both decreased （P 〈 0.05）. CONCLUSION： Spontaneously hypertensive has reversible effect on spontaneously hypertensive rat nocieeptive system.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2006年第4期474-476,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
血压
痛阈
机械刺激缩足反应阈值
热刺激缩足反应潜伏期
blood pressure
pain threshold
paw withdrawal mechanical threshold
paw withdrawal thermal latency
