摘要
[目的]探讨宫内生长迟缓(intrauterine growth retardation,IUGR)新生儿是否存在钙磷代谢异常并探讨其临床意义。[方法]分为两组:IUGR儿(即小于胎龄儿,small for gestational age,SGA)组24例,适于胎龄儿(appropriate gestational age,AGA)组30例。采用酶联免疫分析法测定新生儿脐血中骨钙素(osteocalcin,OC)及25-OHD3浓度; 采用全自动生化仪测定新生儿脐血钙、磷、镁的浓度。[结果]与AGA组相比,IUGR组脐血中骨钙素及血磷水平显著降低(分别为t=4．60,P<0．01;t=3．80,P<0．001);骨钙素与出生体重呈正相关(r=0．558,P<0．001);IUGR组脐血钙及25-OHD3两组相比,差异无显著性(t=1．125,P>0．05;t′=1.112,P>0．05)。[结论]IUGR新生儿生后早期钙、磷、镁代谢存在异常。
[Objective] To research for whether the metabolism of calcium and phosphorus in intrauterine growth retardation（IUGR） newborns was abnormal, and research for the clinic use. [Methods] The cases were divided into two groups, intrauterine growth retardation, group （n=24 ） and appropriate gestational age（AGA） grpip （n =30）. The serum OC and 25-OHDs were were measured by Enzyme-Linked Immunosorbent Assag（EIASA）. The calcium, phosphorus and magnesium were measured by auto-biochemistry analysis machine. Comparisons between two groups were used by student＇s T test. The relationship between the levels of OC, phosphorus and magnesium to birth weight and gestational age were assessed by regression analysis. [ Results] The concentrations of OC and phosphorus in IUfJR group were significantly lower than in AGA group （t=4.60, P〈0.01;t= 3.80, P〈0.001 ）. The levels of OC correlated positively to the birth weight （r=0.558,P〈0.001）. The levels of OC didn＇t correlate to the gestational age（r=0.079, P〉0.05）. The levels of phosphorus didn＇t correlated to the birth weight and the gestational age（r=0. 083,P〉0.05;r=0.117, P〉0. 05）. The concentrations of calcium and 25-dihydroxyvitamin D3 were not different between the two groups （t=1.125, P〉0.05 ;t＇=1.112,P〉0.05）. The concentration of magnesium was significantly higher in IUGR group than in AGA group （t=2. 83,P 〈0.05）. The levels of magnesium correlated negatively to the birth weight（r=-0. 483, P〈0.001）, and did not correlate to the gestational age（r=0.056,P〉0.05）. [Conclusion] The results suggested that the metabolism of calcium and phosphorus should be abnormal in IUGR newborns.
出处
《中国儿童保健杂志》
CAS
2006年第3期284-286,共3页
Chinese Journal of Child Health Care
基金
黄岛区科学技术研究项目(2005)
关键词
骨钙素
25-OHD3
钙
磷
镁
宫内生长迟缓
osteocalcin
25-dihydroxyvitation D3
calcium
phosphorus magneisum
intrauterine growth retardation
