摘要
目的:研究石菖蒲挥发油复乳的最佳处方及最佳制备方法,使复乳粒径在10～20μm范围内。方法:采用二步乳化法制备。分别对初乳、复乳的处方进行筛选并考察复乳形成时的搅拌速率、搅拌时间及通入氧气对其粒径的影响。结果:按初乳处方4[石菖蒲挥发油(ml):液状石蜡(ml):司盘-80(g):0．5％明胶溶液(ml):蒸馏水(ml)为1．05:16:7:1:16]制备初乳;再按复乳处方4[初乳(g):吐温-80(g):蒸馏水(ml)为10:1:9]用磁力搅拌机低速搅拌1 min制备的石菖蒲挥发油复乳粒径在10～20μm,所占百分比为72％,且粒度均齐;石菖蒲挥发油复乳以2 L／min的流速通入氧气1 h后,粒径在10～20μm所占百分比由72％增加至79％;石菖蒲挥发油复乳为W／O／W型,且稳定性较好。结论:可以按上述方法制备粒径集中在10～20μm的石菖蒲挥发油复乳。
Objective ： To determine an ideal recipe and technique for making of compound Rhizoma Acori Tatarinowii naphtha emulsion （CRATNE） , diameter for the granule in 10～20μm. Methods： CRATNE was made by two-step emulsification and the recipe was evaluated to investigate the effect of diameter for the granule on stir time and stir speed and oxygen ventilated. Results： The percentages of diameter for the granule in 10×20μm was 72%, Emulsion was made on recipe No. 4 [ Rhizoma Acori Tatafimowii naphtha （ ml）： liquid paraffin （ ml）： Sorbian monooleate （g） ： 0.5% gelatin solution （ ml）： distilled water （ml） is 1.05： 16： 7： 1： 16] and compound emulsion is made on recipe No. 4 [ fore emulsion （g） ： Tween-80 （g）： distilled water （ml） is 10：1：9 ]. Recipe No. 4 was the best one if stiring at low speed through magnetic force mixer was used. Stir time was 1 min. The oxygen was ventilated with a flow rate of 2 L/min for CRATNE. Ventilation time was 1 h. The percentages of diameter for the granule in 10 ～12μm increased from 72% to 79%. was type W/O/W. Conclusion： The diameter of CRATNE for the granule is in 10 ～ 20 μm, can be made following above-mentioned methods.
出处
《中药材》
CAS
CSCD
北大核心
2006年第5期477-479,共3页
Journal of Chinese Medicinal Materials
关键词
石菖蒲
挥发油
复乳
二步乳化法
粒径
Rhizoma Acori Tatarinowii
Naphtha
Compound emulsion
Two-step emulsification
Diameter for the granule
