摘要
目的:总结复发性吉兰-巴雷综合征(RGBS)的临床、神经生理和病理特点。方法:回顾性分析72例患者初发及复发时的临床表现及实验室检查、电生理检查、病理检查及治疗和预后等资料。结果:RGBS的临床病程类似于初次发作,发作间期长短不一(最长23年,最短6个月),两次发作的间隔期患者完全正常。RGBS急性起病且症状进展迅速,脑脊液检查有蛋白-细胞分离现象,电生理异常率增加,病理检查发现髓鞘脱失伴部分再生和轻微轴索变性。结论: RGBS的临床特点类似于典型的GBS,其多次发作可能是相对独立的疾病过程。
Objective： to evaluate the-clinical, neurophysiological pathologic changes in patients with recurrent Guillain-Barré syndrome （RGBS） and their outcome. Methods： We report 72 patients with RGBS out of more than 2000 patients with GBS, who were fulfilled accepted criteria for GBS and they All underwent complete neurological evaluation. All patients were asymptomatic or only mildly symptomatic between attacks. Results： In a given patient, the time to reach peak deficit from the onset of symptoms, the functional grade at peak deficit are shorten than the inicial episodes and the duration of the intervals between episodes varied considerably and unpredictably from one episode to the next. Conclusion： of cerebrospinal fluid （CSF） analysis and nerve conduction studies during recurrences were those expected in typical monophasic GBS or more seriously. On nerve biopsy,more serious damage to myelin and axons were found.
出处
《脑与神经疾病杂志》
2006年第3期165-167,共3页
Journal of Brain and Nervous Diseases
关键词
吉兰-巴雷综合征
复发
脑脊液
电生理
病理
Guillain-Barré syndrome recurrent； cerebrospinal fluid Electrophysiology pathology
