摘要
目的研究坎地沙坦对去甲肾上腺素(norep inephrine,NE)诱导的心肌肥厚大鼠左室舒张功能的影响。方法雌性W istar大鼠29只,随机分为3组:①对照组;②NE组1.2mg/(kg.d)×15d;③NE+坎地沙坦组2mg/(kg.d)×15d。应用病理学方法和超声心动图评价心肌肥厚和左室舒张功能,用免疫组化法和图像分析技术评价心肌纤维化。结果与NE组相比,坎地沙坦组室间隔厚度降低,间质胶原减少,舒张功能改善。结论坎地沙坦能改善去甲肾上腺素诱导的心肌肥厚大鼠左室舒张功能。
Objective To investigate the effect of candesartan on left ventricular diastolic function in cardiac hypertrophic rats induced by NE. Methods 29 female Wistar rats were randomly divided into three groups ： ①control group ; ②NE group 1.2mg/（kg·d）×d, ③ NE ＋ candesartan group 2mg/（kg·d）×15d. The rat cardiac hypertrophy models were established by intraperitoneal injection of NE twice a day for 15 days. Cardiac hypertrophy and left ventricular diastolic function were evaluated by morphological examination and echocardiography. The protein expression of type Ⅰ Collagen,type In Collagen were examined by immunohistochemical analysis. Results After candesartan treatment, the IVST , Collagen decreased, left ventricular diastolic function was improved. Conclusion Candesartan can improve left ventricular diastolic function in cardiac hypertrophic rats induced by NE.
出处
《医药论坛杂志》
2006年第7期9-10,12,共3页
Journal of Medical Forum
关键词
心肌肥厚
心肌纤维化
左室舒张功能
Cardiac hypertrophy
Cardiac fibrosis
Left ventricular diastolic function
