摘要
目的探讨胃癌患者血浆血管内皮生长因子(VEGF)和肿瘤坏死因子(TNF)-α水平的变化及其与胃癌临床病理学特征的关系。方法应用酶联免疫吸附法(ELISA)测定47例胃癌患者血浆VEGF、TNF-α浓度,结合临床病理学资料进行分析。结果胃癌组的血浆VEGF、TNF-α浓度分别为(65．12±29．53)、(8．50±2．91) pg／mL,,均显著高于正常对照组的(32．97±9．79)、(5．20±0．91)pg／mL(P<0．01)。肿瘤浸润深度超过肌层、伴有淋巴结转移、血管浸润者的血浆VEGF和TNF-α明显升高(P值分别<0．05和<0．01);Ⅲ、Ⅳ期亚组的TNF-α值显著高于Ⅰ、Ⅱ期亚组。血浆VEGF与TNF-α呈显著正相关(r=0．663,P<0．05)。结论血浆VEGF、 TNF-α的水平与胃癌肿瘤演进有关,TNF-α浓度与肿瘤分期相关。联合检测VEGF、TNF-α具有一定的临床价值。
Objective To appraise the levels of plasma vascular endothelial growth factor （VEGF）, tumor necrosis factor α （TNF-α） and their correlations with clinicopathological characteristics in gastric cancer. Methods In 47 cases of gastric carcinoma and 20 normal controls, the plasma samples of VEGF and TNF-α were measured by Enzyme-Linked Immunosorhnent Assay （ELISA）. Results The plasma levels of VEGF and TNF-α in gastric carcinoma patients were （65.12±29.53） pg/mL and （8.50±2.91） pg/mL, respectively, and were significantly higher than those of healthy controls （P〈0.01）. Both plasma VEGF and TNF-α levels were higher in patients with deep invasion, lymph node metastasis, and vascular infiltration, TNF-α was also significantly elevated in ad- vanced gastric carcinoma patients （P〈0.05, 〈0.01）. TNF-α of Ⅲ, Ⅳ stage subgroups was significantly higher than those of Ⅰ, Ⅱ stage subgroups. A positive relationship was found between VEGF and TNF-α levels （r = 0.663, P〈0.05）. Conclusion The plasma levels of VEGF and TNF-α are correlated with progression of gastric cancer. TNF-α level is correlated with the tumor stage. Hence, combined determination of the two is of value in clinical practice. VEGF and TNF-α might play an important role in evolution of gastric carcinoma.
出处
《上海医学》
CAS
CSCD
北大核心
2006年第5期290-292,共3页
Shanghai Medical Journal
关键词
胃肿瘤
血管内皮生长因子
肿瘤坏死因子-Α
Gastric carcinoma
Vascular endothelial growth factor
Tumor necrosis factor α
