摘要
Functional dyspepsia （FD） is a common disorder of yet uncertain etiology. Dyspeptic symptoms are usually meal related and suggest an association to gastrointestinal （GI） sensorimotor dysfunction. Cholecystokinin （CCK） is an established brain-gut peptide that plays an important regulatory role in gastrointestinal function. It inhibits gastric motility and emptying via a capsaicin sensitive vagal pathway. The effects on emptying are via its action on the proximal stomach and pylorus. CCK is also involved in the regulation of food intake. It is released in the gut in response to a meal and acts via vagal afferents to induce satiety. Furthermore CCK has also been shown to be involved in the pathogenesis of panic disorder, anxiety and pain. Other neurotransmitters such as serotonin and noradrenaline may be implicated with CCK in the coordination of GI activity. In addition, intravenous administration of CCK has been observed to reproduce the symptoms in FD and this effect can be blocked both by atropine and Ioxiglumide （CCK-A antagonist）. It is possible that an altered response to CCK may be responsible for the commonly observed gastric sensorimotor dysfunction, which may then be associated with the genesis of dyspeptic symptoms.
机能性消化不良(FD ) 是还不明确的病原学的普通混乱。消化不良的症状通常是联系的饭并且建议一个协会到胃肠(官方补给) 感觉运动的机能障碍。缩胆囊素(CCK ) 是在胃肠的功能起一个重要规章的作用的确定的大脑勇气肽。它禁止胃的活动性并且经由辣椒辣素倒空敏感迷走神经小径。倒空上的效果经由它近似的胃和幽门上的行动。CCK 也涉及食物摄取的规定。导致饱足经由迷走神经 afferents 响应饭和幕在内脏被释放。而且， CCK 也被显示了涉及恐慌的混乱，焦虑和疼痛的致病。另外的 neurotransmitters 象血清素那样并且也不肾上腺素可以在官方补给的活动的协作与 CCK 被含有。另外， CCK 的静脉内的管理被观察了在 FD 复制症状，这效果能被颠茄碱和 loxiglumide 两个都堵住(CCK -- 一个对手) 。对 CCK 的改变的回答可能为通常观察的胃的感觉运动的机能障碍负责，是可能的，它然后可以与消化不良的症状的开始被联系。
