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Helicobacter pylori infection causes gastric cancer? A review of the epidemiological,meta-analytic, and experimental evidence 被引量:10

Helicobacter pylori infection causes gastric cancer? A review of the epidemiological,meta-analytic, and experimental evidence
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摘要 Since the discovery of Carnpylobacter-like organisms (Helicobacter pylori) more than two decades ago the possibility of a relationship with gastric cancer has been postulated, tested and supposedly proven. There have been numerous human studies of various designs from many countries around the world. Several meta-analyses have been published and more recently a small number of experimental animal studies were reported looking at the association between Helicobacter pylori infection and gastric cancer. Over the years, the human epidemiological studies have produced conflicting results; the metaanalyses have as one would expect produced similar pooled estimates; while the early experimental animal studies require replication. The exact mechanisms by which H pylori might cause gastric cancer are still under investigation and remain to be elucidated. 自从象 Campylobacter 一样有机体 Helicobacter pylori (H pylori ) 的发现,超过二十年以前,与胃的癌症的一种关系的可能性被要求了,测试并且据说证明。在全世界有来自许多国家的各种各样的图案的众多的人的研究。几元分析被出版了,更最近,实验动物研究的一个小数字被报导看在 H pylori 感染和胃的癌症之间的协会。多年以来,人的流行病学的研究生产了冲突结果;元分析当一个人将期望生产类似的分享的估计,有;当早实验动物研究要求复制时。H pylori 可能由引起胃的癌症的准确机制仍然在调查和遗体下面被阐明。
作者 Guy D Eslick
出处 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第19期2991-2999,共9页 世界胃肠病学杂志(英文版)
关键词 Helicobacter pylori Gastric cancer Metaanalysis Systematic review 幽门螺杆菌 细菌感染 胃癌 免疫学 实验证明
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