摘要
目的探讨IL-8在儿童幽门螺杆菌(H.pylori)感染相关性胃炎中的作用。方法82例患儿在胃镜下取胃窦粘膜活检标本,行组织病理学检查,采用酶联免疫吸附试验(ELISA)法检测胃窦粘膜中IL-8的含量。结果H.pylori阳性患儿胃粘膜IL-8含量为(15.2±5.4)pg/mg,H.pylori阴性患儿胃粘膜IL-8含量为(3.3±1.3)pg/mg,两组比较差异有统计学意义(t=13.315,P<0.001)。不同的H.pylori定植密度其IL-8含量差异无统计学意义(t=1.831,P=0.074)。H.pylori阳性患儿活动性炎症及淋巴滤泡检出率和阴性患儿比较差异有统计学意义(χ2值分别为12.286、6.413,P均<0.01)。活动性胃炎胃粘膜IL-8含量为(20.0±5.0)pg/mg,非活动性胃炎胃粘膜IL-8含量为(12.8±3.8)pg/mg;有淋巴滤泡形成胃粘膜IL-8含量为(21.1±3.4)pg/mg,无淋巴滤泡形成胃粘膜IL-8含量为(13.5±4.7)pg/mg;差异有统计学意义(t值分别为5.306、4.942,P均<0.01)。结论儿童感染H.pylori后胃粘膜上皮组织可检测到高浓度的IL-8,IL-8能引起中性粒细胞浸润及淋巴滤泡形成,提示IL-8在H.pylori感染后胃粘膜组织的炎症反应中具有重要作用。
Objective To explore the possible roles of IL - 8 in H. pylori related gastritis of children. Methods Biopsy specimens were taken from the antral mucosa on endoscopy in 82 patients, histologic mucosal changes were diagnosed by hislogic method and IL - 8 contents examined by ELISA. Results Gastric mucosal IL - 8 contents were higher in H. pylori infected than in non infected children[IL-8： （15.2±5.4） pg/mg, （3.3 ±1.3） pg/mg, t = 13.315, P 〈0.01].The IL-8 contents were not significant in children with different H. pylori colonization density（ t = 1.831, P=0.074）. The detection rate of active gastritis and folliculus lymphaticus were higher in H. pylori infected than in non infected（ X^2 = 12.286,6.413, P 〈0.01 ）. Children with active gastritis and folliculus lymphaticus was higher in IL - 8 contents [ IL - 8 in active gastritis： （20. 0 ± 5.0） pg/mg, （12.81 ±3.81） pg/mg, t =5.306, P 〈0.01. IL-8 in folliculuslymphaticus： （21.1 ±3.4）pg/mg, （13.5±4.7）pg/mg, t= 4. 942 , P 〈 0.01 ]. Conclusion Higher IL - 8 contents were detected in gastric mucosal of H. pylori infected children. 1L -8 affects the adhesion of neutrophils and lymphocytes to the endothelium, and this may explain IL -8 plays an important role in the gastric mucosal inflammation when the children have H. pylori infection.
出处
《临床医学》
CAS
2006年第5期69-70,共2页
Clinical Medicine
关键词
幽门螺杆菌
IL-8
胃炎
儿童
Helicobacter pylori
Interleukin - 8
Gastritis
Children
