摘要
目的探讨嗜铬细胞瘤患者血浆血管紧张素Ⅱ(ATⅡ)的水平及其意义。方法将58例择期全麻下行肿瘤切除术的患者分为3组:正常血压组(Ⅰ组)、原发性高血压组(Ⅱ组)和嗜铬细胞瘤组(Ⅲ组)。测定各组术前及Ⅲ组插管时、挤压肿瘤时、肿瘤切除即刻、肿瘤切除后1,3,5,10,20,30,40和60min的ATⅡ的浓度。结果Ⅱ组,Ⅲ组血浆ATⅡ浓度高于Ⅰ组,差异有统计学意义(P<0.05及P<0.01);Ⅲ组又高于Ⅱ组,差异有统计学意义(P<0.05)。Ⅲ组肿瘤切除即刻、切除后1,3min时点处的ATⅡ浓度低于术前,差异有统计学意义(P<0.05),其余各时点与术前相比,差异无统计学意义(P>0.05)。结论嗜铬细胞瘤患者ATⅡ水平高于正常血压和伴原发性高血压的肿瘤患者。
Objective To explore the levels of serum angiotensin Ⅱand their clinical significance on pheochromocytomas. Methods Fifty-eight patients were randomly divided into three groups： Group Ⅰ with normal blood pressure; Group Ⅱare essential hypertension; Group Ⅲ are pheochromocytomas. The levels of serum angiotensin Ⅱ（AT Ⅱ） in each group and at eleven time points： were measured. Results The levels of serum AT Ⅱ of group Ⅱ and Ⅲwere significantly higher than those of group Ⅰ（P 〈0.05 or P 〈0.01 ）; those in group Ⅲ were higher than in group Ⅱ too（P 〈0.05）. The levels of serum AT Ⅱ were significantly lower at the time of 0,1and 3 minute in group Ⅲ than those before anaesthesia（P 〈0.05）. Conclusion The levels of serum AT Ⅱon pheochromocytomas were higher than those with normal blood pressure and essential hypertension.
出处
《肿瘤研究与临床》
CAS
2006年第5期324-325,共2页
Cancer Research and Clinic
