摘要
目的研究预防免疫阻断乙型肝炎病毒(HBV)父婴传播(P-FT)的价值。方法筛选孕妇丈夫血清HBVDNA(+)、孕妇无HBV感染的患者为研究对象,A组61例,孕前以乙肝疫苗(HBVac)免疫至抗-HBs(+)后再妊娠。于孕28、32、36周分别注射乙肝免疫球蛋白(HBIG)200U。B组60例,仅常规产前检查及监护。新生儿分为A1、B1、B2组,A1、B1组新生儿注射HBVac10μg和HBIG100U,B2组新生儿只注射HBVac10μg。结果A组新生儿HBV感染率为9.84%(6/61),而B组感染率为26.67%(16/60);A1、B2组婴儿6个月龄抗-HBs阳性率分别为88.52%(54/61)和73.33%(22/30),两组比较差异有显著性。结论孕前注射乙肝HBVac,获得免疫后,可显著降低新生儿HBV阳性率;孕期注射HBIG,新生儿出生时应用HBIG和HBVac联合免疫,可以显著提高婴儿6个月龄抗-HBs阳性率。
Objective To investigate the interruptive effect of blocking the paternal - fetal transmission of hepatitis B virus（HBV）. Methods 121 couples of men with serum HBV - DNA positive and women without HBV infection were selected and assigned to study group （group A, 61 couples） and a control group （group B, 60 couples）. Each woman in group A was successfttUy vaccinated with hepatitis B vaccine （HBVac） before pregnancy and injected with hepatitis B specific immunoglobulin （HBIG） monthly in late pregnancy; those in group B did not receive any specific treatment. The newborns were also divided into three Groups： Group A1 and group B1 obtained both HBIG and HBVac, and Group B2 obtained HBVac only. Results 9.84% （6/61）of new - berns in group A and 26.67 % （16/60） in group B were positive of HBsAg ; The anti - HBs positive rate of 6 - month - old infants was significantly higher in Group A1 than that in Group B2. Conclusions Vaccinating HBVac and injecting HBIG before pregnancy may effectively interrupt paternal - fetal transmission ; Vaccinating HBVac and injecting HBIG may also effectively protect infants from infection of HBV.
出处
《浙江临床医学》
2006年第5期458-459,共2页
Zhejiang Clinical Medical Journal
关键词
乙型肝炎病
毒父婴传播
预防免疫
Hepatitis B virus Paternal - fetal transmission Preventive immunization
