摘要
目的 探讨^32P胶体-碘化油乳剂经导管栓塞家犬肝动脉安全性，为临床应用提供依据。方法选择家犬12只，随机分成两组：实验组（放疗栓塞组）、对照组（化疗栓塞组）每组6只。实验组用^32P肢体混合碘化油栓塞肝叶／段动脉；对照组用阿霉素混合同样剂量的碘化油，做同样的栓塞，再从腹腔干动脉灌注5-FU5～10ml。术后即刻行肝脏CT，并定期检测血常规、肝肾功能的变化。分别干术后1、3d和1、2、4、8周对每组犬进行上述检查后处死。观察肝脏大体标本，取被栓塞肝叶，固定、切片、HE染色后做组织学检查，并将各项检查数据进行统计学分析。结果术后1周内两组犬均表现精神饮食差，体重下降；ALT等均表现不同程度地升高，白细胞降低。实验组较对照组血常规、生化指标等无明显变化，变性坏死程度有显著差异（P〈0．05），未出现明地并发症。结论^32P胶体-碘化油乳剂栓塞肝动脉安全可靠，可应用于肝癌临床治疗。
AIM To evaluate the technical feasibility and potential therapeutic effect of P - 32 colloid mixed with Lipiodol as an embolus in the treatment of hepatic malignancies. METHODSTwelve canines were randomly given transcatheter hepatic artery embolization with Lipiodol mixed with either P- 32 colloid of 96, 2 -288.6 MBq（n = 6） or adriamycin of 3 - 5 mg （n = 6）. RESULTS Different degrees of swelling, atrophy, and infarction of the hepatic lobes embolized were observed in both groups macroscopically and microscopically 1 day to 8 weeks after the operations, which was more evident in the P- 32 colloid- treated group（ P 〈 0.05）. CONCLUSION Transcatheter hepatic artery embolization with P- 32 colloid mixed with Lipiodol was feasible and effective with potential therapeutic value in hepatic malignancies.
出处
《中华腹部疾病杂志》
2006年第5期319-321,共3页
Chinese Journal of Celiopathy
关键词
^32P胶体-碘化渍
肝动脉栓塞术
实验
P- 32 colloid
Transcatheter hepatic artery embolization
Animal experiment
