摘要
目的：分析低聚糖类药物成品中残留物N，N-二甲基甲酰胺（DMF）。方法：应用气相色谱法。结果：在FFAP（50m×0．32mm）色谱柱上，DMF与其它组分具有较好的分离效果，分离度〉1．5；DMF浓度在3．58～0．000358mg／mL范围内呈现良好的线性关系，r=0．9999；方法的检测限为1．0mg／mL；对同一试样的5次平行测定的相对标准偏差RSD为1．52％；该法的回收率达95．7％～98．4％。结论：该法操作简单、快速、准确性高、重复性好。
AIM ： The quantitative determination of N,N-dimethylf in olgosaccharide was carried out. METHODS： Gas Chromatographic was employed. RESULTS： Experimental results showed that a good separation of DMF with other contents of sample was achieved on FFAP（50 m×0.32 mm） column, and the separation degree was more than 1.5. The linear range was 3.58 ～ 0. 000358 mg/mL with r = 0. 999 9 and the relative standard deviation was 1.52% （ n = 5 ）. and the limit of detection was 1.0 mg/mL. The recovery of the method was in the range of 95.7%～98.4%. CONCLUSION： The method is simple, rapid,accurate and precise.
出处
《中成药》
CAS
CSCD
北大核心
2006年第5期703-704,共2页
Chinese Traditional Patent Medicine
