摘要
目的探讨老年抑郁症患者脑18氟-脱氧葡萄糖(18F-FDG)正电子发射体层摄影术(PET)显像的特点。方法分别对6例老年抑郁症患者(GD组)及10名健康体检者(对照组)进行脑18F-FDG PET显像,按年龄、简易智力状态检查量表总分和性别构成配对,用统计参数图第2版软件比较两组间脑局部葡萄糖代谢的差别。结果GD组较对照组在双侧尾状核、额下回、颞上回、额中回,右侧核外、额上回、舌回和左侧扣带回、中央前回等脑区局部葡萄糖代谢减低(均P<0.005)。GD组无局部脑葡萄糖代谢增加的脑区。结论老年抑郁症患者存在基底节区、前额叶、颞叶和边缘系统的局部葡萄糖代谢下降。
Objective To investigate brain 18^F-fluorodeoxyglucose （FDG） position emission tomography （PET） mapping in geriatric depression patients. Methods This is a case control study. PET with 18^F-FDG was performed in six geriatric depression patients and ten healthy controls. The two groups were matched with age, sex and the Mini-Mental State Examination （MMSE） score. The voxel level regional glucose metabolic rate were analyzed with the Statistical Parametric Mapping （SPM2） software. Results The regional glucose metabolism rates in bilateral caudate, superior temporal gyrus, inferior frontal gyrus, middle frontal gyrus, fight extra-nuclear, superior frontal gyrus, lingual gyrus and left cingulate gyrus, superior temporal gyrus, sub-gyral and precentral gyrus were decreased in geriatric depression patients than in controls （P 〈 0. 005 ）. There was no significant difference in brain regions with increased glucose metabolism between two groups. Conclusion These results suggest that the glucose metabolism in prefrontal lobes, temporal lobe, limbic system and basal ganglia is decreased in geriatric depressed patients.
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2006年第2期81-84,共4页
Chinese Journal of Psychiatry
基金
上海医学领先专业老年精神医学重点学科资助项目(993030)
