摘要
Eosinophilic esophagitis has rapidly become a recognized entity causing dysphagia in young adults. This review summarizes the current knowledge of eosinophilic esophagitis including the epidemiology, clinical presentation, diagnostic criteria, pathophysiology, treatment, and prognosis. An extensive search of PubMed/Medline （1966-December 2005） for available English literature in humans for eosinophilic esophagitis was completed. Appropriate articles listed in the bibliographies were also attained. The estimated incidence is 43/10s in children and 2.5/10s in adults. Clinically, patients have a long history of intermittent solid food dysphagia or food impaction. Some have a history of atopy. Subtle endoscopic features may be easily overlooked, including a ＂feline＂ or corrugated esophagus with fine rings, a diffusely narrowed esophagus that may have proximal strictures, the presence of linear furrows, adherent white plaques, or a friable （crepe paper） mucosa, prone to tearing with minimal contact. Although no pathologic consensus has been established, a histologic diagnosis is critical. The accepted criteria are a dense eosinophilic infiltrate （〉20/high power field） within the superficial esophageal mucosa. In contrast, the esophagitis associated with acid reflux disease can also possess eosinophils but they are fewer in number. Once the diagnosis is established, treatment options may include specific food avoidance, topical corticosteroids, systemic corticosteroids, leukotriene inhibitors, or biologic treatment. The long-term prognosis of EE is uncertain; however available data suggests a benign, albeit inconvenient, course. With increasing recognition, this entity is taking its place as an established cause of solid food dysphagia.
嗜曙红的食道炎很快成为了在年轻成年人引起咽下困难的一个公认的实体。这评论包括传染病学，临床的演讲，诊断标准，病理生理学，治疗，和预后总结嗜曙红的食道炎的当前的知识。PubMed/Medline 的广泛的搜索(196612 月 2005 ) 为可得到的英语，在为嗜曙红的食道炎的人的文学被完成。在书目列出的适当文章也被达到。估计的发生在成年人在孩子和 2.5/10 (5 ) 是 43/10 (5 ) 。临床上，病人们有断断续续的稳固的食物咽下困难或食物嵌塞的长历史。一些有遗传性过敏症的历史。微妙的内视镜的特征可以容易被俯看，包括有好戒指的一根“猫”或弄皱的食管，可以有近似苛评的一根广泛地缩小的食管，线性沟的存在，支持者白人匾，或一脆(绉绸纸) 粘膜，对与最小的接触撕敏感。尽管没有病理学的一致被建立了， histologic 诊断是批评的。接受标准是一稠密嗜曙红渗入(>20/high 力量地) 在表面的食道的粘膜以内。相反，食道炎与酸倒流疾病联系了能也拥有嗜曙红血球，但是他们是在数字的少数。一旦诊断被建立，治疗选择可以包括特定的食物回避，热门 corticosteroids，全身的 corticosteroids， leukotriene 禁止者，或生物学的治疗。EE 的长期的预后是不明确的；然而可得到的数据建议一良性，虽然不方便，路线。与增加识别，这个实体作为稳固的食物咽下困难的一个确定的原因正在占据它的位置。
