摘要
Background Middle mediastinal masses comprise a wide variety of tumors but may also reflect lymphadenopathy, and thus remain an interesting diagnostic challenge. We performed positron emission tomography （PET） of mediastinal masses in order to evaluate the ability of PET to predict the malignancy of these tumors. We compared histologic findings, videomediastinoscopy, computed tomography （CT）, and PET-CT in patients with mediastinal disease. Methods Thirty-two patients were evaluated with CT, PET-CT and videomediastionoscopy, and all studies were performed within four weeks in each patient. ^11C-choline as a PET tracer was used to visualize masses. PET data were evaluated using the standardized uptake value （SUV） and were compared with pathologic data. Results There were 13 men and 19 women aged from 21 to 74 （mean 45.2） years. Among the patients with mediastinal diseases, sarcoidosis was diagnosed in 12 patients, tuberculosis in 5 patients, lymphoma in 5 patients, and noncaseating granulomata without classical ＂sarcoid＂ finding in 3 patients. N2 or N3 nodal metastasis was revealed in 6 of 7 patients who had non-small cell lung cancer or suspected lung cancer, and one was negative （the pathological diagnosis was reactive hyperplasia）. The accuracies for correctly diagnosing mediastinal masses for CT, PET-CT and videomediastinoscopy were 38% （12/32）, 63% （20/32）, and 91% （29/32） respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of PET-CT （X^2=11.130, P〈0.001）. The SUVs were similar among these diseases. On the other hand, if the diagnostic classification was benign vs malignancy, the accuracies for CT, PET-CT and videomediastinoscopy were 53% （17/32）, 75% （24/32）, 100% （32/32） respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of PET-CT （X^2=22.042, P〈0.001）. The SUV of malignant lesions （6.9, 3.2-9.8; n=11） appeared to be higher than that of benign lesions （4.9, 2.9-8.3; n=21）, howev
Background Middle mediastinal masses comprise a wide variety of tumors but may also reflect lymphadenopathy, and thus remain an interesting diagnostic challenge. We performed positron emission tomography （PET） of mediastinal masses in order to evaluate the ability of PET to predict the malignancy of these tumors. We compared histologic findings, videomediastinoscopy, computed tomography （CT）, and PET-CT in patients with mediastinal disease. Methods Thirty-two patients were evaluated with CT, PET-CT and videomediastionoscopy, and all studies were performed within four weeks in each patient. ^11C-choline as a PET tracer was used to visualize masses. PET data were evaluated using the standardized uptake value （SUV） and were compared with pathologic data. Results There were 13 men and 19 women aged from 21 to 74 （mean 45.2） years. Among the patients with mediastinal diseases, sarcoidosis was diagnosed in 12 patients, tuberculosis in 5 patients, lymphoma in 5 patients, and noncaseating granulomata without classical ＂sarcoid＂ finding in 3 patients. N2 or N3 nodal metastasis was revealed in 6 of 7 patients who had non-small cell lung cancer or suspected lung cancer, and one was negative （the pathological diagnosis was reactive hyperplasia）. The accuracies for correctly diagnosing mediastinal masses for CT, PET-CT and videomediastinoscopy were 38% （12/32）, 63% （20/32）, and 91% （29/32） respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of PET-CT （X^2=11.130, P〈0.001）. The SUVs were similar among these diseases. On the other hand, if the diagnostic classification was benign vs malignancy, the accuracies for CT, PET-CT and videomediastinoscopy were 53% （17/32）, 75% （24/32）, 100% （32/32） respectively. The diagnostic accuracy of videomediastinoscopy was superior to that of PET-CT （X^2=22.042, P〈0.001）. The SUV of malignant lesions （6.9, 3.2-9.8; n=11） appeared to be higher than that of benign lesions （4.9, 2.9-8.3; n=21）, howev
基金
This study was supported by a grant from Shangdong Provincial Ministry of Science and Technology (No. 2004BS03018).
