摘要
目的:探讨卡托普利对高血压患者颈动脉粥样硬化(AS)的逆转作用。方法:将70例经彩色多普勒超声证实有颈AS的高血压患者随机均分为治疗组和对照组,治疗组35例在对照组常规治疗基础上服用卡托普利12．5 mg,tid,治疗6个月及12个月经彩色多普勒超声测定颈动脉内膜中膜厚度(IMT)、斑块病变类型、血管内径及血流参数,并与治疗前对比。结果:①2组患者血脂水平治疗前后无明显改变。②治疗组中Ⅰ型患者治疗后12个月从治疗前的57．14％减少到20％(P<0．05),而对照组无明显改变;治疗组患者治疗前后相比,或与同期对照组比较差异有统计学意义(P<0．05),2组Ⅱ-Ⅳ型患者治疗前后均无明显改变。③治疗组治疗后1MT 降低,血管内径增加;且随疗程延长,效果更明显,而对照组却无相应变化。④治疗组治疗后颈总动脉、颈内动脉的血管阻力指数均较治疗前明显降低,收缩期峰速度、舒张期末速度和血管搏动指数则较治疗前呈显著性增加, 且随疗程延长,有进一步降低或增加趋势,但对照组却无类似变化。结论:卡托普利可减轻血管IMT,改善血管的顺应性,降低血管阻力,改善颈动脉血流,随着治疗时间延长其效应更为显著。
Objectve;The to investigate effects of captopril on the regression of carotid atherosclerosis in the patients with hypertension. Method：Seventy patients with carotid atherosclerosis in the patients were randomly divided into treatment group and control group. Thirty-five patients of treatment group were treated with captopril 12.5 mg 3 times per day and their carotids were checked by Doppler to determine carotid intima media thickness （IMT）, type of carotid atheromatous plaques, carotid inner diameters and blood flow spectrum parameter in 6 and 12 months after treatment. Result： ①Serum lipid levels of treatment group had no significant differences compared with control group before and after treatment. ②The patients of type I in treatment group were decreased significantly from 57. 14% to 20% （ P 〈0.05） after 12 months, treatmmeat. No change was showed in the control group. There were significantly differences correlation between treatment before and after and same term of con- trol group in both groups, while type-Ⅲ was only slightly changes between two groups. ③The IMT of carotid after captopril therapy was reduced significantly and initical diameter was significantly enlarged in treatment group, their effect was more remarkable with treatment prolonged, but control group was not significantly change. ④RI of CCA and ICA after treatment in treatment group were significantly decreased and SPV, EDV and Pl were sig nificantly increased compare with before treatment （ P 〈0.05, P 〈0.01）, but all the parameters of control group had no obvious significance. Conclnsion;Captopril has regression effect on reduced IMT and improved blood vessel elasticity and compliance as well as decreased vessel resistance in carotid, their effect was more remarkable as the time of treastment prolonged.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2006年第5期291-294,共4页
Journal of Clinical Cardiology
关键词
颈动脉
动脉粥样硬化
卡托普利
高血压
Carotid arteries ； Atherosclerosis；Captopril
Hypertension
