摘要
目的:观察维吾尔族男性急性冠状动脉综合征(ACS)患者血清脂蛋白(a)[LP(a)]、血浆纤溶酶原激活抑制物-Ⅰ(PAI-Ⅰ)及血浆纤维蛋白原(Fg)水平变化并分析其相关性。方法:维吾尔族男性119例,分为2组: ACS组66例,对照组53例;分别测定其血清LP(a)、血浆PAI-Ⅰ和血浆Fg水平。结果:ACS组、对照组血清LP (a)分别为(422．323±201．685)、(146．60±80．984)mmol／L;2组血浆PAI-Ⅰ含量吸收度(A值)分别为(1．276 ±0．831)和(0．369±0．418);血浆Fg水平分别是(4．688±0．970)、(3．515±0．507)g／L,2组间差异均有统计学意义(P<0．05)。将119例研究对象,按LP(a)分为≤300 mmol／L组和>300 mmol／L,比较2组PAI-Ⅰ含量和 Fg水平:LP(a)>300 mmol／L组(55例)A值为(1．182±0．842),Fg为(4．563±0．980)g／L;LP(a)≤300 mmol／ L组(64例),A值为(0．605±0．691),Fg为(3．824±0．864)g／L,经秩和检验2组间差异具有统计学意义(P< 0．01)。血清LP(a)与血浆PAI-Ⅰ含量相关分析,r=0．427,P<0．01;血清LP(a)与血浆Fg进行相关分析,r =0．441,P<0．01。结论:血清LP(a)、血浆PAI-Ⅰ和血浆Fg水平在维吾尔族男性ACS患者中明显增高;血清 LP(a)水平高者血浆PAI-Ⅰ及Fg亦有较高水平,血清LP(a)水平与血浆PAI-Ⅰ、Fg水平间呈正相关。维吾尔族男性LP(a)、PAI-Ⅰ和Fg水平增高与其冠心病临床事件的发生有关。
Objective： To investigate the changes and the correlation between lipoprotein（a）（LP[a]）, plas minogen activator inhibitor- Ⅰ（PAI-Ⅰ） and fibrinogen（Fg） in uigur male patients with acute coronary syndromes （ACS）. Method： The serum LP（a）,absorb（ A ） of the plasma plasminogn activator inhibitor-Ⅰ and the plasma Fibrinogen were detected in 119 uigur males. Sixy-six patients with acute coronary syndromes were enrolled as ACS group;the other 53 patiens without coronary heart disease（CHD） were enrolled as control group. Result： There were significant differences in serum LP（a）, plasma PAI- Ⅰ , and Fg between the ACS group and the control group （LP（a） E422. 323±201. 685]mmol/L vs E146.60±80. 984]mmol/L; PAI-Ⅰ[1.275 8±0. 831 2]vs E0. 368 6±0. 417 8]; Fg[4. 6883±0. 969 7]g/L vs [3. 5145±0. 5068]g/L, P 〈0.05. The levels of PAI- Ⅰ in the subjects with LP（a）〉300mmol/L（ n 55）were 1. 182 5±0. 841 7,and the levels of Fg in them were （4. 562 5±0. 979 7） g/L, while the levels of PAI- Ⅰ with LP（a） ≤300 retool/L（ n =64） were 0. 6047 7 ±0. 6905 7,and their levels of Fg were （3. 824 4± 0. 864 0）g/L. There were significant differences between two groups . There is positive correlation between the levels of LP（a） and PAI- Ⅰ （ r =0. 427, P 〈0. 001） ,and between the levels of LP（a） and Fg （ r = 0. 441, P 〈0.01）. Conclusion：The Uigur male patients with ACS had significantly increased levels of LP（a） ,PAF-Ⅰ ,Fg, and the subjects who had higher levels of LP（a） had higher levels of PAI-Ⅰ and Fg simultaneously. It proved that LP（a） ,PAI- Ⅰ and Fg may be risk factors of CHD in Uigur male patients.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2006年第5期282-284,共3页
Journal of Clinical Cardiology
