摘要
目的探讨血清β—HCG在输卵管妊娠保守性治疗后疗效观察的价值及其相关因素。方法回顾性分析保守性治疗输卵管妊娠145例,其中药物治疗组62例(A组),单纯保守性手术38例(B组),保守性手术加术中输卵管局部注射甲氨蝶呤(MTX)10mg45例(C组)。治疗后定期监测血清β—HCG变化并分析相关因素。结果A组中保守治疗成功58例,4例保守治疗失败改手术治疗。C组术后血清β—HCG下降至正常时间明显短于A组(P<0.01)和B组(P<0.05)。治疗前血清β—HCG浓度高者,治疗后降至正常所需时间长,但在A组中无明显相关性。结论连续监测血清β—HCG对异位妊娠保守性治疗后疗效观察及预防持续异位妊娠极为重要。手术中采用输卵管局部注射MTX可缩短手术后血清β—HCG恢复至正常的时间。
Objective To investigate and evaluate the value of serum β-HCG levels in curative effect observation after conservative treatment of ectopic pregnancy and its correlative factors. Methods 145 patients suffering from fallopian pregnancy were reviewed. On basis of the therapy, they were divided into three groups： group A （medical treatment） with 62 patients, group B （single conservative surgical management） with 38 patients and group C （conservative surgical management with injection of methotrexate （MTX） 10mg into fallopian tube locally） with 45 patients. After therapy, serum β-HCG concentration was measured and analyzed termly. Results 58 patients were successfully treated by medical treatment and 4 patients failed in medical treatment underwent surgery instead in group A. The periods that posttreatment serum β-HCG concentration descended to normal level in group C were significantly shorter than those in group A and group B and the ones that posttreatment serum β-HCG concentration descended to normal level were longer among those whose serum β-HCG levels were higher before treatment. But there was no correlation in group A. Conclusions Close serum β-HCG levels surveillance is critical for curative effect observation after conservative treatment of ectopic pregnancy and prevention of the onset of persistent ectopic pregnancy. Injection of MTX into fallopian tube locally in conservative surgical management can shorten the periods of postoperative serum β-HCG concentration being normal.
出处
《海南医学》
CAS
2006年第6期47-49,共3页
Hainan Medical Journal
