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阻断细胞外信号调节激酶活性对乙醛刺激的大鼠肝星状细胞功能的影响 被引量:3

Effects of ERK deactivation on functions of rat cultured hepatic stellate cells stimulated by acetaldehyde
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摘要 细胞外信号调节激酶(ERK)信号通路参与调控细胞增殖与分化,其在乙醛刺激的肝星状细胞(HSC)活化中的意义鲜见报道。我们观察了特异性阻断剂PD98059阻断ERK活性后对乙醛刺激的HSC增殖、Ⅰ型胶原分泌、转化生长因子β1(TGFβ1)mRNA及Na^+/Ca^2+交换蛋白表达的影响,以探讨ERK在调控乙醛刺激HSC激活及其活化后功能改变中的作用,为肝纤维化的防治提供理论依据。
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2006年第5期386-387,共2页 Chinese Journal of Hepatology
基金 全军十五医药卫生科研基金(01MB037)
关键词 有丝分裂素激活蛋白激酶类 转化生长因子Β 钠钙交换 蛋白 肝星状细胞 Mitogen-activated protein kinases Transforming growth factor beta Sodium-calcium exchanger Hepatic stellate cell
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参考文献5

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二级参考文献9

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