期刊文献+

胸腺素α1的研究进展 被引量:1

The Development in Thymosin α1
下载PDF
导出
摘要 胸腺素α1是机体内的一种免疫活性肽,目前已用于乙型、丙型肝炎及恶性肿瘤、免疫缺陷等疾病的研究和临床治疗中。其作用机制尚不十分清楚,一般被认为具有生物反应调节物的功能。现对胸腺素α1的分布、作用机制及临床应用进行综述,并总结胸腺素α1在生物制备上的进展。 Thymosin α1 (Tα1) was an immune active peptide in vivo. It was used in the treatment of hepatitis B, hepatitis C, tumors and immune-deficiency syndrome. It was generally considered as an important biological response modifier, though the mechanisms of Tα1 was still not well mastered. Here, we reviewed the distribution, mechanism model of functions, and clinical application of Tα1, and summarized its recent development in biosynthesis.
出处 《细胞生物学杂志》 CSCD 2005年第6期621-624,共4页 Chinese Journal of Cell Biology
关键词 胸腺素Α1 生物反应调节物 临床应用 thymosin α1 biological response modifier clinical application
  • 相关文献

参考文献7

二级参考文献49

  • 1Goldstein AI,Low TL,McAdoo M,et al. Thymosin alpha 1 :isolation and sequence analysis of an immunologically active thymic polypeptide[J]. Natl Acad Sci, 1977 ; 74 : 725. 被引量:1
  • 2Sarandeses CS, Covelo G, Diaz-Jullien C,et al. Prothymosin alpha is processed to thymosin alpha 1 and thymosin alphal 11 by a lysosomal asparaginyl endopeptidase[J]. J Biol Chem, 2003, 278(15):13286. 被引量:1
  • 3Low TL,Thurman GB,Chincarini C,et al. Current status of thymosin research:evidence for the existence of a family of thymic factors that control T-cell maturation[J]. J Bioi Chem. 1979. 254(3):987. 被引量:1
  • 4Hicklin DJ, Marincola FM, Ferrone S. HLA class I antigen down-regulation in human cancers:T-cell immunotherapy revivesan old story[J]. Mol Med Today,1999,5:178. 被引量:1
  • 5Ohmori H,Kamo M,Yamakoshi K,et al. Restoration of immunocyte functions by thymosin alpha 1 in cyclophosphamide-induced immunodeficient mice [J ]. Immunopharmacol Immunotoxicol.2001,23 (1) : 75. 被引量:1
  • 6Amarapurkar D,Das HS,et al. Thymosin alpha in the treatment of chronic hepatitis B:an uncontrolled open-label trial[J]. Indian J Gastroenterol, 2002,21 (2) : 59. 被引量:1
  • 7Sarue M, Yuceyar H, Kucukmetin N, et al. Combination thymosin-alpha 1 and interferon-alpha 2b in the treatment of antiHBe-positive chronic hepatitis B in Turkey [J]. Hepatogast roenterology, 2002,49 (45) : 798. 被引量:1
  • 8Lau GK,Nanji A ,Hou J ,et al. Thymosin-alpha 1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase[J].Viral Hepat, 2002,9 (4) : 280. 被引量:1
  • 9Andreone P, Cursaro C, Gramenzi A, et al. A double-blind.placebo-controlled,pilot trial of thymosin alpha 1 for the treatment of chronic hepatitis C[J]. Liver, 1996,16(3):207. 被引量:1
  • 10Andreone P.Cursaro C,Gramenzi A,et al. In vitro effect of thymosin-alpha 1 and interferon-alpha on Thl and Th2 cytokine synthesis in patients with chronic hepatitis C[J]. J Viral Hepat,2001.8(3) :194. 被引量:1

共引文献73

同被引文献18

  • 1计慧琴,王丙云,陈志胜,江青艳.T细胞的发育分化及胸腺激素的作用[J].动物医学进展,2005,26(4):47-50. 被引量:15
  • 2钟英英.胸腺肽的研究现状和临床应用[J].中南药学,2005,3(2):116-118. 被引量:10
  • 3王丽华.胸腺肽致糖尿病2例报告.中华实用医学杂志,2005,5(13):346-347. 被引量:2
  • 4Rebar R W, Morandini L C, Erickson G F, et al. The hormonal basis of reproductive defects in athym ic: diminished gonadotropin concentrations in prebubertal females[J]. Endocrinology, 1981, 108: 120. 被引量:1
  • 5Coe C L, Hall M R. Psychological disturbance alters thymic and adrenal hormone secreationin a parallel but independent manner[J]. Psyehoneuroendocrinology, 1996, 21(2): 237-247. 被引量:1
  • 6Wise T. In vitro and in vivo effects of thymulin on rat testicular steroid synthesis[J]. Steroid Biochem Mol Biol, 1998, 66(3):129-135. 被引量:1
  • 7Eugenio M, Attilio C, Lory S, et al. Zinc, thymic endocrine activity and mitogen responsiveness (PHA) in piglets expose tomaternal aflatoxicosis Bland G[J]. Vet Immunol Immunopathol, 1998, 62: 245-260. 被引量:1
  • 8欧阳五庆.动物生理学[M].北京:科学出版社,2009:287-288. 被引量:1
  • 9Velkov Z, Zafirova M, Kemileva Z, et al. Time course changes in blood glucose and insulin levels of thymeetomized rats [J]. Acta Physiol Pharmacol Bulg, 1990, 16(2): 64-68. 被引量:1
  • 10陈蓉.胸腺肽注射剂127例不良反应分析[J].中国医院药学杂志,2008,28(8):680-681. 被引量:7

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部