摘要
随着人类基因组研究计划(hum an genom e project,HGP)DNA序列测定工作的迅速发展,研究人类基因组变异越来越受到重视。基因组变异最常见的一种形式就是单核苷酸多态性(single nuc leotide polymorph ism,SNPs),SNPs已成为继限制性酶切片断长度多态性(restriction fragm ent length polymorph ism,RFLP)和微卫星之后的第3代遗传标记,大规模的SNPs鉴定和SNP公共数据库已经建立。研究SNPs不仅有利于基因组测序,更有利于复杂性疾病相关基因的研究和药学基因组学的发展。
Along with the rapid development of DNA sequencing in human genome project （HGP） ,researches on human genovariation become more and more important. The most common form of human genovariation is single nucleotide polymorphism （SNPs）. As a marker secondary to restriction fragment length polymorphism （RFLP） and microsatellite, SNPs has been the third generation of genetic marker. Large-scale SNPs identification and public SNP database have been set up, researches on SNPs have great significance in revealing the essence of llfe. It not only contribute to genome sequencing, but also can supply useful information for the further study of disease related gene and the development of pharmacogenomics.
出处
《国际病理科学与临床杂志》
CAS
2006年第2期152-155,共4页
Journal of International Pathology and Clinical Medicine
基金
浙江省自然科学基金(M303818)
浙江省医药卫生科研基金(2002ZX010
2003A020)
