摘要
目的比较糖耐量正常（NGT）、单纯空腹血糖受损（I—IFG）、单纯糖耐量低减（I-IGT）、糖耐量低减合并空腹血糖受损（IGT／IFG）和新诊断的2型糖尿病（2型DM）5种不同糖代谢状态的微量自蛋白尿（MAU）发病率，并对MAU危险因素进行多因素回归分析。方法根据75g口服葡萄糖耐量试验（75gOGTT）结果，将898例受试者分为：NGT组162例、I—IFG组186例、I—IGT组230例、IGT／IFG组146例、新诊断的2型DM组174例。用放射免疫法测定过夜12h尿白蛋白。UAE在20—200μg／min之间定义为MAU。结果（1）MAU的发病率在新诊断的2型DM组为19．5％、IGT／IFG组为13．0％、I—IGT组为11．7％，均高于I—IFG组的6．5％（P〈0．05），I—IFG组与NGT组比较差异无统计学意义（P〉0．05）。（2）多因素Logistic回归分析显示，导致MAU危险性增加的因素有OGTT 2h血糖、舒张压、体重指数的升高和高密度脂蛋白胆固醇的降低。结论I—IGT人群已经出现MAU发病率的升高，并且IGT—IFG和新诊断的2型DM人群升高更为明显；而上述指标I—IGT人群与正常人群之间的比较差异无统计学意义。提示在糖代谢异常早期，与空腹血糖的升高相比，餐后高血糖对MAU的影响更大。
Objective To compare the difference of glucose tolerance （NGT）, isolated impaired fasting glucose （I - IFG）, isolated impaired glucose tolerance （I- IGT）, impaired glucose tolerance combined with impaired fasting glucose （IGT/IFG） and newly diagnosed type 2 diabetes mellitus （T2 DM）, and to probe the risks for vascular diseases by comparison of microalbuminuria （MAU） prevalence in the five subjects mentimed above. Methods A total of 898 subjects recruited in the study were divided into 5 groups based on 75g oral glucose tolerance test （OGTT） results： 162 cases in NGT, 186 in I - IFG, 230 in I - IGT, 146 in IGT- IFG, 174 T2 DM cases newly diagnosed respectively. UAE was detected with radio immunoassay,MAU was defined if UAE was between 20 - 200μg/min. Results （ 1 ） The prevalences of MAU in the newly diagnosed ＇I2 DM 19.5 %, IGT - IFG group 13.0 %, and I - IGT group 11.7% were all higher than that in I - IFG group 6.5% （P 〈 0.05） respectively.MAU was comparable between I - IFG group and NGT group 6.2% （P 〉 0.05） . （2） Multiple Logistic regression analysis showed that the risk factors for MAU were elevation of BMI, DBP and OGTT2 HBG, while high- density lipoprotein cholesterol was a protective factor. Conclusion It is suggested that in early stage of abnormal glucose tolerance, postprandial hyperglycemia might be a more important risk factor for the prevalence of MAU than isolated fasting hyperglycemia.
出处
《中国预防医学杂志》
CAS
2006年第2期108-111,共4页
Chinese Preventive Medicine
关键词
微量白蛋白尿
糖尿病
糖耐量低减
空腹血糖受损
Microalbuminuria
Diabetes mellitus
Impaired glucose tolerance
Impaired fasting glucose
