摘要
对２４例子宫肌瘤患者血清雌、孕激素及多处子宫组织的雌、孕激素及其受体进行测定。结果显示：宫肌瘤组织雌二醇（Ｅ２），Ｅ２胞浆受体（ＥｃＲ）、孕激素胞浆受体（ＰｃＲ）、和Ｅ２胞核受体（ＥｎＲ）的含量均显著高于正常子宫肌组织（Ｐ＜０．０５～０．００１）；且增生期肌瘤组织Ｅ２与ＥｃＲ正相关ｒ＝０．７０，Ｐ＜０．０５，血Ｅ２及孕酮（Ｐ）与各处宫肌组织Ｅ２及Ｐ无关；瘤旁子宫肌与正常宫肌的组织激素和受体含量无显著差异。另１６例子宫肌瘤患者用三苯氧胺（ｔａｍｏｘｉｆｅｎ，ＴＡＭ）治疗４．３个月后子宫体积缩小，其中１０例兼行手术者的瘤组织Ｅ２及ＥｎＲ水平显著下降，镜下可见广泛退行性变及坏死。研究提示：宫肌瘤局部可能形成异常高的Ｅ２及Ｅ２受体（ＥＰ）环境，肌瘤的发生存在多中心性趋势。ＴＡＭ可抑制瘤组织对Ｅ２摄取和ＥｃＲ的核转移，并使核保留减少，从而降低ＥｎＲ的含量，达到治疗子宫肌瘤的目的。
he E2 and P concentration in the serum and myoma tissue of 24 patients were deter- mined. The receptors of E2 and P in the tissue also determined. The authors found that the concentration of E2 , the cytosolreceptor of E (EcR ) , P (PcR) and nuclear receptor of E (EnR) in the myoma tissue were significantly higher than that of normal uterine tissues (P < 0. 05 ～0. 001 ). E2 and EcR in leiomyoma demonstrated a significant positive correlation during proliferative phase (r = 0. 70 , P< 0. 05). No relation was observed between E2 , P concentration in serum and that in uterine tissue. There are no significant differences in tis- sues E2 , P and their receptors between normal uterine tissues and myometrium juxta leiomy- oma. Fourteen patients with leiomyomas were treated with tamoxifen (TAM) for 4. 3 mon- thes. The uterine volume was markedly decreased , the high levels of E2 and EnR of their leiomyomas were also decreased significantly (10 cases received hysterectomy) . Large areas of various degenerative changes and necrosis were seen upon microscopic examination. This study suggest that abnormal higher concentrations of E2 and EcR exist in leiomyoma , the growth of leiomyoma may occur in maltiple center. TAM may decrease intake of E2 from pe- ripheral blood and reduce the concentration of EnR in leiomyoma. Therefore , it can be used in the treatment of leiomyoma effectively.
出处
《中山医科大学学报》
CSCD
1996年第2期107-110,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
肌瘤
受体
激素
三苯氧胺
子宫肿瘤
uterine neoplosms/drug therapy
receptors , estrogen/analysis re- ceptors , progesterone/analysis
tamoxifen/therapeutic use
