摘要
目的探讨水飞蓟宾磷脂酰胆碱复合物(SPC)对脓毒症肝脏损伤的保护作用。方法将50只Wistar幼鼠随机分为对照组(10只)、脓毒症组(30只)、干预组(10只)。脓毒症组采用盲肠结扎穿刺术(CLP)致脓毒症模型;干预组于CLP术前和术后2 h予SPC灌胃;对照组除不进行CLP外余同脓毒症组。各组均观察外周血TNF-αI、L-1和ALT、AST水平变化。结果脓毒症组血TNF-αI、L-1和ALT、AST水平明显升高,与对照组比较有显著性差异(P均<0.01);而干预组中上述指标变化较脓毒症组明显减轻(P均<0.01)。结论脓毒症时早期应用SPC治疗,对肝脏有一定保护作用。
Objective To investigate the hepatoprotective effect of silybin -phosphatidylcholine complex（SPC） in sepsis rats. Methods Fifty Wistar immature rats were randomly divided into 3 groups： normal control （10 cases）, septic group （30 cases） and interference group （10 eases）. In septic group and interference group, rats were treated by cecal ligation and puncture（CLP）. Meanwhile, the interference group was given SPC before 2 hours of CLP and after 2 hours of CLP. Blood of rats was taken from all groups to determine the levels of serum tumor necrosis factor-α （ TNF-α ）, interieukin-1 （ IL-1 ）, alanine aminotransferase （ALT） and aspartate aminotransferase （AST） at varying intervals. Results The levels of serum TNF-α, IL-1, ALT and AST after CLP were significantly elevated in .septic group compared with the normal control group （P 〈 0.01 ）. There was great significant difference between septic group and interference group in markers mentioned above （ P 〈 0.01 ）. Conclusion In early septic period, SPC may play an important proteetivc role in liver function.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第9期547-548,共2页
Journal of Applied Clinical Pediatrics
基金
河南省科技攻关项目资助(001180203)
