摘要
目的：为提高胃泰颗粒喷雾干燥制粒颗粒的成品率及降低半成品颗粒的含水量,需要筛选制备工艺.方法：采用喷雾干燥制粒机制粒并在流化床上进行干燥,以浸膏的提取工艺、进出口的风温及辅料的配比为考察因素,每个因素三个水平,以颗粒的成品率及半成品颗粒的含水量为考察指标,采用正交设计法优选出最佳喷雾干燥制备工艺.结果：三因素中以辅料的配比影响最为显著（P＜0.01）,其次为进出口风的温度（P＜0.05）,浸膏的提取工艺影响不大（P＞0.05）.结论：胃泰颗粒最佳的喷雾干燥工艺条件为A3B1C3,即蔗糖与乳糖的配比为3：1;进风口的温度为90℃～100℃;出风口的温度为50℃～60℃;提取液以水提法较经济.
Objective： To screen preparntion tchnique in order to raise the end-product and economical efficiency of spray-drier preparation technology of weitai granules. Methods ： Newly Fluid-bed-spray-drier-granulation technique was adoped and taken extracting technique, temperature of exit and entry and the matching of accessories as inspecting factors, two levels of each factors, end-product and the water content of semi-finished weitai granules as inspecting marker, the best preparation technique of weitai granules was screened by orthogonal desing. Results ： Among the 3 factors, the matching of accessories was most notalbe （ P 〈 0. 01 ）, next was the temperature of exit and entry （ P 〈 0. 05）. However, the extracting technique was of little importance （ P 〉 0. 05 ）. Conclusion ： The optimum spray-drier granulation technique of weitai granules is A3 B1 C3.
出处
《中药材》
CAS
CSCD
北大核心
2006年第4期390-392,共3页
Journal of Chinese Medicinal Materials
关键词
喷雾干燥
颗粒剂
制备工艺
正交实验
Spray-Drier
Granules
Preparation Technology
Orthogonal Experiments
