摘要
主要组织相容性复合体(MHC)是和免疫反应直接相关的基因群。MHCⅠ类分子的多态性和病原体的多变性相对应,它是个体在重大传染疾病中存活下来的重要依据。在灵长类动物进化过程中,由于分化时间的差异和生存压力的不同,造成了各物种MHCⅠ类基因不同的存在状态,使它们的MHCⅠ类基因在基因数量和基因功能上有所差异,同时还产生了物种特异性基因。文章描述了灵长类MHCⅠ类基因的总体变化特征,并着重讨论了6个典型MHCⅠ类基因在各典型灵长类物种中的特点及关联性。
The major histocompatibility complex （MHC） is a gene cluster directly related to immune response. The highly polymorphic nature of the MHC class Ⅰ genes corresponds to variations of the pathogens and are crucial for individual survival during infection. During primate evolution, the diverse forms of MHC class Ⅰ genes came to existence due to different time of divergence and survival pressure. Over time, this led to changes in the number as well as the function of these genes, and even the emergence of species-specific genes. In this paper we describe the overall features of primate MHC class Ⅰ genes, with an emphasis on the characteristics of six classical MHC class Ⅰ genes in the typical primate species and their interrelationships.
出处
《遗传》
CAS
CSCD
北大核心
2006年第5期611-616,共6页
Hereditas（Beijing)
