摘要
目的评价小剂量曲安奈德玻璃体腔内注射治疗黄斑水肿的效果和安全性。方法31例(31眼)黄斑水肿患者,其中糖尿病性黄斑水肿19例、视网膜中央静脉阻塞性黄斑水肿8例、白内障术后黄斑水肿4例,所有患者均行6mg曲安奈德玻璃体腔内注射。在注射后1周、1个月、2个月、3个月对患者视力、眼压进行检查并行黄斑部光相干断层扫描检查黄斑区视网膜厚度和黄斑区视网膜总容积。结果所有患者的视力在注射后均有一定升高,经LogMAR转换后注射前和注射后3个月视力分别为0.620±0.334和0·455±0·313(P<0.05);黄斑区视网膜厚度和容积下降,注射后3个月分别为(312±146)μm和(2.61±0.27)mm3,与注射前相比[(484±216)μm和(3.76±0.56)mm3]差异有显著性意义(P<0.05)。随访1周、1个月、2个月时的平均眼压[(18.1±6.4)mmHg、(18.9±6.3)mmHg、(17.6±5.8)mmHg,1kPa=7.5mmHg]较注射前平均水平[(14.2±4.6)mmHg]显著升高(P<0.05)。随访期内1例患者因白内障进展而需手术治疗。结论至少3个月随访期内,小剂量曲安奈德玻璃体腔内注射治疗黄斑水肿安全有效,没有严重并发症。
Objective To evaluate the effect and safety of intravitreal injection of low-dose triamcinolone acetonide （TA） on cystoid macular edema. Methods Thirty-one patients（31 eyes, including 19 cases of diabetic macular edema, 8 cases of macular edema caused by branch retinal vein occlusion and 4 cases of macular edema after cataract surgery） underwent intravitreal injection of 6 mg TA. At the time of 1 week, 1 month, 2 months, 3 months after the injection, the visual acuity, intraocular pressure, thickness of the macular fovcal and total volume of macula were examined. Results Three months after injection, the visual acuity of all patients was increased significantly compared with that before injection （0.620 ± 0. 334 vs 0. 455 ± 0.313, P 〈 0.05, after LogMAR conversion）. Thickness of the macular foveal and total volume of the macula were decreased clearly after 3 months＇ s follow-up[ （312 ± 146） μm and （2.61 ± 0. 27） mm^3] compared with those before injection [（484 ±216） μm and （3.76 ± 0.56） mm^3, P 〈 0.05, respectively]. The mean lntraocular pressure was increased remarkably at the follow-up time of 1 week, 1 month and 2 months [ （ 18.1 ± 6.4 ） mmHg, （ 18.9 ± 6.3 ） mmHg, （ 17.6 ± 5.8）mmHg] compared with those before injection [ （ 14.2 ±4.6） mmHg, P 〈 0.05 respectively]. One case underwent phacoemulsification surgery due to cataract development during the follow-up period. Conclusion Intravitreal injection of low-dose triamcinolone acetonide is effective on macular edema patients within 3 months of the follow-up period and no serious complications have been found in this study.
出处
《眼科新进展》
CAS
2006年第5期372-374,共3页
Recent Advances in Ophthalmology
关键词
曲安奈德
黄斑囊样水肿
玻璃体内注射
trlamclnolone acetonlde
cystold macular edema
intravitreal injection
