摘要
目的观察DF方案化疗合并放射治疗老年中晚期食管癌的疗效及其毒副反应.方法将50例老年中晚期食管癌患者随机配对分为两组行前瞻性临床研究.一组25例放射治疗开始行DF方案化疗（综合组）,另一组25例行单纯放疗（单放组）.放射治疗均采用6 MV X线常规分割外照射,靶区剂量为50～60 Gy.结果综合组和单放组放疗半量时有效率（CR＋PR）分别为68.0%和36.0%（P＜0.05）;放疗全量时有效率分别为88.0%和64.0%（P＜0.05）.综合组食管炎发生率为48.0%,单放组为24.0%（P＜0.05）.综合组52.0%患者出现白细胞减少,单放组20.0%患者出现白细胞减少（P＜0.05）.其他毒副反应差异无显著性.结论DF方案化疗合并放射治疗能显著提高老年中晚期食管癌患者的局控率,近期疗效显著.毒副反应明显加重,但经过积极治疗,患者可以耐受.
Objective To observe the results and side effects of chemotherapy with DF combined with radiotherapy in treatment of advanced esophageal cancer in the aged. Methods From February 2004 to March 2005, a prospective randomized trial on chemotherapy （C） with DF combined with radiotherapy （R） for advanced esophageal cancer in the aged was carried out in 50 patients. The patients were randomized into combined group（ R ＋ C, 25 patients） or radiotherapy alone group （ R,25 patients）. 8MV photon was used for all patients, delivering 60-70 Gy. Results In R ＋ C group and R group, the clinical response rate of half dose was 68.0% and 36.0% respectively（P 〈 0.05） and that of total dose was 88.0% and 64.0% respectively （ P 〈 0.05 ）. The rate of esophagitis was 48.0% and 24.0% respectively（ P 〈 0.05 ）. The rate of WBC toxicity grade Ⅰ ＋ Ⅱ ＋ Ⅲ was 52.0% and 20.0% respectively（ P 〈 0.05 ）. Conclusions Chemotherapy with DF combined with radiotherapy for advanced esophageal cancer in the aged improved radiosensitivity and local control rate compared with histological control and there were no serious side effects.
出处
《中国肿瘤临床与康复》
2006年第2期175-177,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
食管肿瘤/化学疗法
食管肿瘤/放射疗法
Esophageal neoplasms/chemotherapy
Esophageal neoplasms/radiotherapy
