摘要
目的:用动态血压监测(ABPM)方法进行厄贝沙坦和比索洛尔对比研究来评价厄贝沙坦治疗轻、中度高血压的有效性及安全性。方法:62例轻、中度高血压患者随机分为2组,分别服用厄贝沙坦150-300mg和比索洛尔5-10mg,每日 1次,在治疗前后8周采用24小时ABPM评价降压效果。结果:治疗后两组病人的血压均有明显下降,厄贝沙坦组24h平均收缩压(SBP)由治疗前(147．3±9．4)mmHg降至(132．2±10．6)mmHg,舒张压(DBP)由治疗前(94．7±7．5)mmHg降至治疗后(83．2±9．7)mmHg,SBP、DBP谷／峰比值分别为分别69％、72％,比索洛尔组24h平均SBP由治疗前(146．8±9．2) mmHg降至(133．4±10．3)mmHg,DBP由治疗前(94．4±6．8)mmHg降至治疗后(84．5±10．5)mmHg,SBP、DBP谷／峰比值分别为65％、68％。两组均有较好的降压效果,血压较治疗前明显降低(P<0．01),但两组间血压下降差别无统计学意义 (P>0．05)。8周末厄贝沙坦组总有效率为77％,比索洛尔组为74％。不良反应发生率两组间比较无显著性差异(P> 0．05)。结论:厄贝沙坦150-300mg,每日1次,对轻、中度高血压病疗效确切,可维持24小时的降压作用。
Objective： To evaluate the efficacy and safety between irbessrtan and bisoprolol in the patients with mild - to - moderate essential hypertension by ABPM（ambulstory blood pressure monitoring） .Methods： 62 patients with essential hypertension were randomized two group, 31 eases to irbesartan treatment group（irbosartan 150- 300mg/d） and 31 cases to bisoprolol treatment group （bisoprolal 5 - 10mg/d） after a 2- week wasbout period. 24h blood pressure monitoring was carried out by ABPM foflowing 8 week＇ s treatment.Results： After treatment blood pressure significantly decreased in both greups. SBP decreased from（ 147.3 ＋ 9.4）mmHg to （132.2＋ 10.6） mmHg, DBP decressed from （94.7＋ 7.5）mmHg to （83.2＋9.7）mmHg, T/ P of SBP and DBP was 69% and 72% in irbesartan group, SBP decreased from （146.8＋ 9.2） mmHg to （133.4＋ 10.3）mmHg, DBP decreased from （94.4＋6.8） mmHg to （84.5 ＋ 10.5）mmHg,T/P of SBP and DBP was 65% and 68% in bisoprolol. （compared with before treatment P 〈 0.01）. No significantly difference between two groups for blood pressure （P 〉 0.05） .At 8- week, the total efficacy rate in ibesartan group was 77% and in bisoprolol greup was 74% ,respectively（P 〉 0.05） .The adverse events were no significant between the two treatment groups（ P 〉 0.05）, Conclusion： Irbesattan was effective in patients with mild - to - modorate essential hypertension and prduce sustained 24h blood pressure control.
出处
《中国医药导刊》
2006年第2期121-123,共3页
Chinese Journal of Medicinal Guide
