摘要
利用聚乙二醇和丙交酯在辛酸亚锡的催化作用下开环聚合了分子量可控的可降解的二羟基中间体,在NaH存在的条件下形成大分子活性醇钠盐溶液,与环氧氯丙烷均相反应,制备了双环氧基封端的生物可降解交联剂。使用GPC对中间体进行了分子量测定。讨论了反应的影响因素,测定了交联剂的环氧值。应用交联剂对壳聚糖进行交联,并对交联材料进行了吸水率、表面接触角及力学性能的测定。结果表明,最佳的反应条件是投料质量比1∶2,反应时间4 h,反应温度60℃时,交联剂的环氧值为1.034 mmol/g。新型生物降解交联剂的运用不仅改善了材料吸水性,也提高了材料的力学性能。
A series of biodegradable crosslinkers terminated by double epoxy groups was prepared from epoxypropane chloride and the intermediates of poly （ lactic acid） -poly （ ethylene glycol） （PLA-PEG-PLA） in the presence of Nail. The molecular weights of the intermediates were measured with GPC. The optimized process parameters were obtained by orthogonal trials. The crosslinker terminated with active epoxy groups was used to react with chitosan which has many amido and hydroxy groups. The crosslinked materials were characterized by water absorbency, surface contact angle and mechanical property analyses. The results of the orthogonal trials indicated that the crosslinker was best prepared at 40 ~ for 4 h in a reactant ratio of 1：2, and the epoxy value was 1. 034 mmol/g. The test of water absorption and surface contact angles and tensile tests showed that both the hydrophilicity and the mechanical properties of the crosslinked chitosan had been improved.
出处
《应用化学》
CAS
CSCD
北大核心
2006年第4期414-418,共5页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(30500128)
广东省自然科学基金(04300673)资助项目
