摘要
目的利用腮腺显像研究鼻咽癌放疗后腮腺的摄取与排泄功能。方法 48例鼻咽癌患者中,对38例肿瘤和肿大淋巴结行加速调强放疗(SMART),其亚临床灶和预防照射区接受常规照射;余10例行常规放疗。放疗前后均行腮腺显像,计算腮腺的放射性摄取指数(UI)及酸性刺激后排泌指数(EI),对腮腺功能损伤情况进行分析;同时记录患者口干程度并分级。结果鼻咽癌 SMART组放疗后腮腺 UI 和 EI 分别下降21.9%和37.3%,中重度口干者12例;而常规放疗组腮腺功能明显下降,UI 和 EI 分别下降56.1%和96.1%,中重度口干者9例,两者比较差异均有显著性(P<0.05)。结论腮腺显像可灵敏地监测鼻咽癌放疗后腮腺功能。
Objective To study the uptake and excretion function of parotid by radionuclide imaging after simultaneous modulated accelerated radiation therapy （SMART） in nasopharyngeal cancer. Methods Forty-eight nasopharyngeal cancer cases, 38 of them were treated by SMART with 2.5 Gy/fraction at tumor and enlarged lymph node to a total dose of 70 Gy, and 2.0 Gy/fraction at subclinical foci and prophy laxtic area volume to a total dose of 56 Gy in 38 d. The other 10 cases were treated by traditional radiation therapy （RT）. After treatment, all patients performed parotid imaging and both uptake index（UI） and excretion index （ EI ） after acid stimulation were calculated. Clinical manifestation such as grade of mouth dryness was also analyzed. Results Average UI and EI in SMART group decreased 21.9% and 37.3% respectively, with 12 cases moderate and severe mouth dryness, whereas in traditional RT group, mean UI and EI decreased 56. 1% and 96.1% respectively, with 9 cases morderate and severe mouth dryness. There was significant difference between them （ P 〈 0.05 ）. Conclusion Parotid imaging is sensitive for monitoring parotid function, and it is also reliable to evaluate the safety of SMART to parotid.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2006年第2期95-96,共2页
Chinese Journal of Nuclear Medicine
