摘要
肿瘤坏死因子相关的凋亡诱导配体(tumornecrosisfactor-relatedapoptosis-inducingligand,TRAIL)是肿瘤坏死因子(tumornecrosisfactor,TNF)超家族的成员之一,它能选择性诱导肿瘤细胞凋亡,对大多数正常细胞无杀伤作用。研究表明,某些恶性肿瘤抵抗TRAIL诱导的凋亡,且TRAIL重复作用使一些TRAIL敏感的细胞产生获得性抗性,这是TRAIL应用于肿瘤治疗的重大障碍。现对与TRAIL凋亡诱导通路直接相关的抗TRAIL机制及由Akt等途径介导的抗性分子机制进行综述。
Tumor necrosis factor （TNF）-related apoptosis-inducing ligand （TRAIL） is one of several members of the TNF gene super-family that selectively induces apoptosis of tumor cells, but not normal cells. However, several recent researches show that numbers of malignant tumors cells are resistant to apoptosis induced by TRAIL, and repeated application of TRAIL protein to some cancer cells that were originally sensitive to TRAIL- induced apoptosis results in acquired resistance. This review summarized the resistant mechanisms targeted the apoptosis pathway induced by TRAIL, and the molecular mechanisms of resistance mediated by other TRAIL activated pathway, such as Akt pathway.
出处
《细胞生物学杂志》
CSCD
2006年第2期153-159,共7页
Chinese Journal of Cell Biology
基金
国家自然科学基金资助项目(No.30100115)~~
