摘要
普瑞巴林是神经递质γ-氨基丁酸(GABA)的一种类似物,能阻断电压依赖性钙通道,减少神经递质的释放。临床用于治疗外周神经痛、糖尿病性外周神经病(DPN)引起的疼痛、疱疹后神经痛(PHN)及部分癫痫发作的辅助治疗。对其药理作用、药动学及临床应用评价进行综述。
Pregabalin is a gamma-aminobutyric acid （GABA） analogue with analgesic, anxiolytic and anticonvulsant activities. It reduces the release of neurotransmitters by interfering with the calcium channels at nerve terminals. Clinically, it has been used to treat peripheral neuropathic pain associated with diabetic peripheral neuropathy （DPN）, postherpetic neuralgia （PHN） and as an adjunctive treatment for epilepsy. This paper reviewed the mechanism, pharmacokinetics and clinical evaluation of pregabalin.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2006年第7期569-571,共3页
Chinese Journal of New Drugs
