摘要
目的探讨原发性非小细胞肺癌(NSCLC)中p21WAF/c ip的表达及与临床病理特征之间的关系。方法采用免疫组织化学(S-P法)检测80例NSCLC组织标本和40例肺良性病变组织中p21WAF/c ip的表达水平。结果①NSCLC组织中p21WAF/c ip表达水平(76.3%)明显高于肺良性病变组织(25.0%)(P<0.01);②NSCLC中p21WAF/c ip表达水平与肺癌组织学类型,P-TNM分期无关(P>0.05),与细胞分化程度,是否有淋巴结转移存在相关性(P<0.01);③NSCLC中p21WAF/c ip表达水平升高与患者是否长期大量吸烟存在相关性(P<0.01)。结论p21WAF/c ip与肿瘤的发生、发展关系密切。
Objective To investigate the role of p21^WAF/cip in non -small cell lung cancer（NSCLC）. Methods The expression of p21^WAF/cip was detected in 80 NSCLC samples and 40 lung benign lesion tissues as control by immunohistochemistry（ S - P）. Results ①The expression level of p21^WAF/cip was found to be significantly higher in NSCLC tissues than in benign lesion tissues （ P 〈 0.01 ）;② p21^WAF/cip was closely related to cancer cell differentiation and lymph node involvement The expression level of in lung cancer patients （ P 〈 0.05） ;but was not related to histological classification and P- TNM stages; ③The expression level of p21^WAF/cip was closely related to lasting and heavy smoking. Conclusion p21^WAF/cip is may be closely related to the pathogenesis and development of lung cancer.
出处
《中原医刊》
2006年第8期18-19,共2页
Central Plains Medical Journal
