摘要
蛋白酪氨酸磷酸酶-1B(PTP-1B)是胰岛素信号转导的主要负调控因子,对2型糖尿病的发生、发展有重要作用。PTP-1B通过使胰岛素受体及其底物酪氨酸去磷酸化而阻断胰岛素的信号转导。2型糖尿病患者和动物模型PTP-1B的表达水平和活性均明显提高,引起胰岛素抵抗,而PTP-1B 基因敲除鼠胰岛素敏感性却升高。因此,深入研究PTP-1B及其有效的抑制剂对于2型糖尿病的治疗具有良好的发展前景。
As the primary negative regulator in the insulin signaling pathway, protein tyrosine phosphatase- 1B（PTP-1B） plays an important role in the onset and development of type 2 diabetes. PTP-1B dephosphorylates phosphotyrosine residues of the active insulin receptor and insulin receptor substrates, and disrupts the insulin signal transduction.The level and activity of PTP-1B are significantly increased in type 2 diabetes patients and experimental diabetic animal models with insulin resistance. In contrast, the insulin sensitivity is improved in PTP-1B knockout mice. Thus, the in-depth research on PTP-1B and PTP-1B inhibitors appears to be a very attractive candidate for the therapy of type 2 diabetes.
出处
《国际内分泌代谢杂志》
2006年第B04期6-8,共3页
International Journal of Endocrinology and Metabolism
