摘要
目的研究有轻度认知损伤的人群中可能存在的不同亚型,以便为轻度认知损伤患者的临床转归及痴呆的早期干预提供依据。方法选取简易智能状态检查、临床记忆量表、词语流畅性、数字广度、画钟表和相似性测验,从10个不同认知领域利用心理测评结果对58例轻度认知损伤患者进行聚类分析。所有轻度认知损伤患者可聚为3类,分别为36例、14例和8例。结果在3个类别之间有5项认知功能(临床记忆量表、画钟表测验、词语流畅性测验、数字广度测验、相似性测验)差异有显著性意义。结论在轻度认知损伤患者中可能主要存在三种亚型,一是以单纯记忆功能减退为主;二是多个认知领域轻度损伤;三是以非记忆功能减退为主;不同亚型的认知损伤范围和临床转归不同。
Objectives To clearly understand the concept of mild cognitive impairment in order to make early diagnosis and provide treatment for dementia, and to investigate the potential existence of isoforms among the population with mild cognitive impairment. Methods Psychological test results of 10 different cognitive areas were analyzed for clustering in 58 patients with mild cognitive impairment and the following test methods were used： mini-mental state examination, clinical memory scale, word fluency, figure wideness, clock drawing and similarity test. Results All patients with mild cognitive impairment could be grouped into 3 categories：36 in category 1,14 in category 2 and 8 in category 3. There were significant differences in 5 cognitive functions among the three categories. Conclusions There may be 3 isotbrms in the patients with mild cognitive impairment. The first is characterized by memory loss, the second is characterized by mild multiple cognitive function impairment and the third is characterized by non-memory impairment. The scopes of cognitive impairment and clinical prognosis are different between different isoforms of mild cognitive impairment.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2006年第3期187-189,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
关键词
阿尔茨海默病
认识障碍
遗传异质性
干预性研究
Alzheimer disease
cognition disorders
genetic heterogeneity
intervention studies
