摘要
目的观察口服弥凝片治疗鞍区肿瘤术后尿崩症的疗效。方法观察单剂量试验(单次口服弥凝片0.1mg)和两周试验(口服弥凝片0.1mg3次/天,口服两周)前后的尿量、尿渗透压等指标的变化。结果22例病人单次口服弥凝0.1mg后,尿量迅速下降,约为服药前的1/8,尿渗透压上升为服药前l0倍,此作用维持(12.52±3.81)h。服药两周后,尿量较前减少至(2155±360)ml/d;血渗透压上升达(312.32±5.26)mOsm/kg,单剂量和两周试验服药前后尿量和尿渗透压比较,差异有统计学意义,P<0.05。用药期间无一例有不良反应。结论口服弥凝片治疗鞍区肿瘤术后尿崩症疗效明确安全方便。
Objective To observe the effect of oral minirin in postoperative parasellar neoplasm patients with central diabetes insipidus. Methods Changes in the urine volume and osomlality after one single dose of minirin （0. 1mg） and after two weeks of minirin medication （0. 1mg, 3 times each day） were observed in 22 patients. Results The urine volume reduced significantly and urine osmolality increased after a single dose of minirin（0.1mg） ,and this action lasted （ 12.52 ± 3.81） h after two weeks of minirin therapy , the urine volume decreased to （2155 ±360） ml/d , and plasmas osmolarity increased to （312.32 ± 5.26） mOsm/kg. Adverse reaction didn＇ t appear during the therapy. Conclusion Minirin is effective and safe in the therapy of postoperative parasellar neoplasm patients with central diabetes insipidus.
出处
《全科医学临床与教育》
2006年第2期105-107,共3页
Clinical Education of General Practice
关键词
弥凝
中枢性屎崩症
鞍区肿瘤术后
minirin
central diabetes insipidus
parasellar neoplasm after operation
