摘要
目的：对比血管紧张素Ⅱ（AngⅡ）受体拮抗剂缬沙坦和血管紧张素转换酶抑制剂（ACEI）洛汀新对心力衰竭患者心室重塑及心功能的影响，探讨缬沙坦逆转心室重塑、改善心功能的作用。方法：心力衰竭患者100例，左室射血分数（LVEF）≤45％，心功能Ⅱ～Ⅳ级，随机分为对照组、缬沙坦组和洛汀新组。常规治疗基础上缬沙坦组加缬沙坦80mg／d，顿服，洛汀新组加洛汀新10mg／d，顿服，治疗16周，观察缬沙坦和洛汀新对心室重塑及心功能的影响。应用心脏彩色超声仪分别测定基线值、治疗后4周、16周左室结构及功能指标变化。结果：经过16周治疗后，对照组临床症状、心功能分级、心室收缩功能及心室重塑指标略有改善，而缬沙坦组和洛汀新组均明显改善。结论：AngⅡ受体拮抗剂缬沙坦能明显改善心力衰竭患者的心功能和逆转心室重塑。长期应用可改善衰竭心脏心肌细胞的生物学效应，这种有益的作用与ACEI类药物洛汀新相似。
Objective： To study the effect of valsartan on the reversal of left ventricular remodeling and the improvement of left ventricular function by comparing the effects of angiotensin 11 and antagonist - valsartan and angiotension enzyme inhibitors - lotensin in the patients with cardiac failure.Methods： 100 cases of cardiac failure with ejection fraction ≤0.45 persent were divided randomly into control group, valsartan group and lotensin group. In addition to basic to medical therapy, valsartan group was given valsartan 80mg/d and lotensin group was given lotensin 10mg/d for 16 weeks, and the effects of valsartan and lolensin on left ventricular remodeling and left ventricular function were observed. Results： After 16 weeks, the symptom, NYHA class,left ventricular systolic and diastolic performance and left ventricular remodeling were improved slightly in control group, while in valsartan group and lotensin group were improved significantly. There was no significant difference between valsartan group and lotensin group. Conclusion： Valsartan therapy can significandy improve left ventricular performance and reverse left ventricular remodeling in patients with heart failure,and also improve the biological properties of the failing heart. There was no difference in the benefit to the patients between valsartan group and lotensin group.
出处
《医学理论与实践》
2006年第4期380-382,共3页
The Journal of Medical Theory and Practice
关键词
缬沙坦
洛汀新
充血性心力衰竭
心室重塑
Valsartan, Lotensin, Congestive heart failure,Left ventricular remodeling
