摘要
目的 研究高发区广东省鼻咽癌的家族聚集性规律，为反映高发区鼻咽癌的遗传流行病学特点及遗传咨询提供资料。方法 收集1998年1月～2000年8月在中山大学肿瘤防治中心治疗的全部广东籍初诊鼻咽癌患者共1142例的病案资料。按照事先制定的调查表，收集患者的一般资料及家族中的肿瘤情况。结果 在广东籍人群中，21．9％的鼻咽癌患者具有肿瘤家族史，其中12．3％的患者有鼻咽癌家族史。家族中肿瘤患者70％左右发生于一级亲属中，家族中鼻咽癌患者在父母和兄弟姐妹中发生的比率相当。广东省内高发区的患者亲属同患鼻咽癌的比例为19．8％，明显高于省内其他地区同患鼻咽癌的比例8．5％，χ^2=0．236，P〈0．01。结论 在鼻咽癌高发区广东省，鼻咽癌具有显著的家族聚集性，而且越高发的地区其家族聚集性越强。
Objective To study the family clusting regulation of nasopharyngeal carcinoma（NPC） in Guangdong province, so as to provide informations for genetic epidemiology and clinical genetic consultation. Methods The data about family cancers and general information of 1 142 NPC patients between January 1998 and August 2000 who were treated in Cancer Center of Sun Yat-sen University were collected by using well-designed statistic forms. All of these patients were Cantonese and had not been treated before. Results In NPC patients of Guangdong, 21.89% patients＇ families had various tumors and 12. 3% patients families only had NPC. Most of the NPC patients family cancers（70%）occurred in the first degree relatives and the NPC incidence was equal between the NPC patients＇ parents and brothersisters. The NPC incidence of the patients relatives was obviously higher in the high risk are as（19.8%） than the low risk are as（8. 5%） of NPC, χ^2 = 30. 236,P〈0. 01. Conclusion There was obviously family clustering in the NPC patients of Guangdong and where the higher incidence place, the more obviously family clustering of NPC could been found.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第4期283-285,共3页
Cancer Research on Prevention and Treatment
关键词
鼻咽癌
流行病学
家族聚集性
Nasopharyngeal Carcinoma （NPC）
Epidemiology
Family Clustering
